TY - JOUR
T1 - Cytotoxic effect of capsicum annum l. Extract on t47d cells
T2 - In vitro study
AU - Kurnijasanti, Rochmah
AU - Fadholly, Amaq
N1 - Publisher Copyright:
© RJPT All right reserved.
PY - 2021/6
Y1 - 2021/6
N2 - Capsicum annum L. is a potential natural plant that have a lot of various pharmacological effects, including as anticancer agent. This study Aim to analyze Capsicum annum extract (CAE) on T47D cells. CAE (10, 20, 40, 60, 80µg/mL) treated on T47D cells to determined IC50 value by MTT assay. Apoptosis induction is also investigated through caspase-3 expressions (IC50, 2IC50). The present study showed that CAE suppress T47D cells proliferation with IC50 value of 75.81µg/mL. The caspase-3 expression on 2IC50 is higher (67.16%) than IC50 (52.16%). This result indicate that CAE has ability as anticancer agent by inhibiting cell growth and induce apoptosis through caspase-3 expression on T47D cells. Further study of CAE holds potential for novel therapies of cancer prevention and treatment.
AB - Capsicum annum L. is a potential natural plant that have a lot of various pharmacological effects, including as anticancer agent. This study Aim to analyze Capsicum annum extract (CAE) on T47D cells. CAE (10, 20, 40, 60, 80µg/mL) treated on T47D cells to determined IC50 value by MTT assay. Apoptosis induction is also investigated through caspase-3 expressions (IC50, 2IC50). The present study showed that CAE suppress T47D cells proliferation with IC50 value of 75.81µg/mL. The caspase-3 expression on 2IC50 is higher (67.16%) than IC50 (52.16%). This result indicate that CAE has ability as anticancer agent by inhibiting cell growth and induce apoptosis through caspase-3 expression on T47D cells. Further study of CAE holds potential for novel therapies of cancer prevention and treatment.
KW - Apoptosis
KW - Capsicum annum
KW - Cytotoxicity
UR - http://www.scopus.com/inward/record.url?scp=85112716126&partnerID=8YFLogxK
U2 - 10.52711/0974-360X.2021.00589
DO - 10.52711/0974-360X.2021.00589
M3 - Article
AN - SCOPUS:85112716126
SN - 0974-3618
VL - 14
SP - 3389
EP - 3392
JO - Research Journal of Pharmacy and Technology
JF - Research Journal of Pharmacy and Technology
IS - 6
ER -