Cytotoxic effect of capsicum annum l. Extract on t47d cells: In vitro study

Rochmah Kurnijasanti, Amaq Fadholly

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Capsicum annum L. is a potential natural plant that have a lot of various pharmacological effects, including as anticancer agent. This study Aim to analyze Capsicum annum extract (CAE) on T47D cells. CAE (10, 20, 40, 60, 80µg/mL) treated on T47D cells to determined IC50 value by MTT assay. Apoptosis induction is also investigated through caspase-3 expressions (IC50, 2IC50). The present study showed that CAE suppress T47D cells proliferation with IC50 value of 75.81µg/mL. The caspase-3 expression on 2IC50 is higher (67.16%) than IC50 (52.16%). This result indicate that CAE has ability as anticancer agent by inhibiting cell growth and induce apoptosis through caspase-3 expression on T47D cells. Further study of CAE holds potential for novel therapies of cancer prevention and treatment.

Original languageEnglish
Pages (from-to)3389-3392
Number of pages4
JournalResearch Journal of Pharmacy and Technology
Volume14
Issue number6
DOIs
Publication statusPublished - Jun 2021

Keywords

  • Apoptosis
  • Capsicum annum
  • Cytotoxicity

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