TY - JOUR
T1 - Cytotoxic effect of capsicum annum l. Extract on t47d cells
T2 - In vitro study
AU - Kurnijasanti, Rochmah
AU - Fadholly, Amaq
N1 - Funding Information:
Authors would like to thank the Departments of Veterinary Basic Medicine, Faculty of Veterinary Medicine, Universitas Airlangga. Special thanks to PMDSU Scholarship by The Ministry of Research, Technology, and Higher Education of the Republic of Indonesia which was awarded to Amaq Fadholly.
Publisher Copyright:
© RJPT All right reserved.
PY - 2021/6
Y1 - 2021/6
N2 - Capsicum annum L. is a potential natural plant that have a lot of various pharmacological effects, including as anticancer agent. This study Aim to analyze Capsicum annum extract (CAE) on T47D cells. CAE (10, 20, 40, 60, 80µg/mL) treated on T47D cells to determined IC50 value by MTT assay. Apoptosis induction is also investigated through caspase-3 expressions (IC50, 2IC50). The present study showed that CAE suppress T47D cells proliferation with IC50 value of 75.81µg/mL. The caspase-3 expression on 2IC50 is higher (67.16%) than IC50 (52.16%). This result indicate that CAE has ability as anticancer agent by inhibiting cell growth and induce apoptosis through caspase-3 expression on T47D cells. Further study of CAE holds potential for novel therapies of cancer prevention and treatment.
AB - Capsicum annum L. is a potential natural plant that have a lot of various pharmacological effects, including as anticancer agent. This study Aim to analyze Capsicum annum extract (CAE) on T47D cells. CAE (10, 20, 40, 60, 80µg/mL) treated on T47D cells to determined IC50 value by MTT assay. Apoptosis induction is also investigated through caspase-3 expressions (IC50, 2IC50). The present study showed that CAE suppress T47D cells proliferation with IC50 value of 75.81µg/mL. The caspase-3 expression on 2IC50 is higher (67.16%) than IC50 (52.16%). This result indicate that CAE has ability as anticancer agent by inhibiting cell growth and induce apoptosis through caspase-3 expression on T47D cells. Further study of CAE holds potential for novel therapies of cancer prevention and treatment.
KW - Apoptosis
KW - Capsicum annum
KW - Cytotoxicity
UR - http://www.scopus.com/inward/record.url?scp=85112716126&partnerID=8YFLogxK
U2 - 10.52711/0974-360X.2021.00589
DO - 10.52711/0974-360X.2021.00589
M3 - Article
AN - SCOPUS:85112716126
SN - 0974-3618
VL - 14
SP - 3389
EP - 3392
JO - Research Journal of Pharmacy and Technology
JF - Research Journal of Pharmacy and Technology
IS - 6
ER -
