Cytotoxic constituents from the stem bark of chisocheton pentandrus

Rurini Retnowati, Hermin Sulistyarti, Nikmatus Zahro Wahidah, Anisa Lailatusy Syarifah, Suprianto Salam, Nurlelasari, Agus Safari, Desi Harneti, Mulyadi Tanjung, Ace Tatang Hidayat, Rani Maharani, Unang Supratman, Yoshihito Shiono

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Eight cytotoxic constituents, consisting of six triterpenoids, cabralealactone (1), cabraleadiol (2), prototiamin A (3), 23-desmethyllimocin B (5), melianodiol (7) and indicalilacol (8) along with one limonoid, neemfruitins A (4) and one protolimonoid, protoxylocarpin G (6), were isolated from the extract of n-hexane of the stembark of Chisocheton pentandrus. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. These isolated compounds appear for the first time in the plant. Compounds 1-8 were evaluated for their cytotoxic effect against MCF-7 breast cancer lines in vitro. Among the isolated compounds, melianodiol (7) showed the strongest cytotoxic activity with IC50 values of 16.8 μM.

Original languageEnglish
Pages (from-to)18-27
Number of pages10
JournalNatural Product Sciences
Issue number1
Publication statusPublished - 2021


  • -Chisocheton pentandrus
  • Limonoid
  • MCF-7 cell lines
  • Meliaceae
  • Triterpenoids


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