TY - JOUR
T1 - Cytotoxic constituents from the stem bark of chisocheton pentandrus
AU - Retnowati, Rurini
AU - Sulistyarti, Hermin
AU - Wahidah, Nikmatus Zahro
AU - Syarifah, Anisa Lailatusy
AU - Salam, Suprianto
AU - Nurlelasari,
AU - Safari, Agus
AU - Harneti, Desi
AU - Tanjung, Mulyadi
AU - Hidayat, Ace Tatang
AU - Maharani, Rani
AU - Supratman, Unang
AU - Shiono, Yoshihito
N1 - Funding Information:
This investigation was financially supported by Universitas Brawijaya, Indonesia (PPKI Grant, No: 455.5/ UN10.C10/PN/2020 by RR); (Universitas Padjadjaran, Indonesia (PPKI Grant, No: 1427/UN6.3.1/LT/2020 by US) and Universitas Airlangga, Indonesia (PPKI Grant, No: 305/UN3.14/PT/2020 by MT).
Publisher Copyright:
© 2021, Korean Society of Pharmacognosy. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Eight cytotoxic constituents, consisting of six triterpenoids, cabralealactone (1), cabraleadiol (2), prototiamin A (3), 23-desmethyllimocin B (5), melianodiol (7) and indicalilacol (8) along with one limonoid, neemfruitins A (4) and one protolimonoid, protoxylocarpin G (6), were isolated from the extract of n-hexane of the stembark of Chisocheton pentandrus. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. These isolated compounds appear for the first time in the plant. Compounds 1-8 were evaluated for their cytotoxic effect against MCF-7 breast cancer lines in vitro. Among the isolated compounds, melianodiol (7) showed the strongest cytotoxic activity with IC50 values of 16.8 μM.
AB - Eight cytotoxic constituents, consisting of six triterpenoids, cabralealactone (1), cabraleadiol (2), prototiamin A (3), 23-desmethyllimocin B (5), melianodiol (7) and indicalilacol (8) along with one limonoid, neemfruitins A (4) and one protolimonoid, protoxylocarpin G (6), were isolated from the extract of n-hexane of the stembark of Chisocheton pentandrus. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. These isolated compounds appear for the first time in the plant. Compounds 1-8 were evaluated for their cytotoxic effect against MCF-7 breast cancer lines in vitro. Among the isolated compounds, melianodiol (7) showed the strongest cytotoxic activity with IC50 values of 16.8 μM.
KW - -Chisocheton pentandrus
KW - Limonoid
KW - MCF-7 cell lines
KW - Meliaceae
KW - Triterpenoids
UR - http://www.scopus.com/inward/record.url?scp=85108533581&partnerID=8YFLogxK
U2 - 10.20307/nps.2021.27.1.18
DO - 10.20307/nps.2021.27.1.18
M3 - Article
AN - SCOPUS:85108533581
SN - 1226-3907
VL - 27
SP - 18
EP - 27
JO - Natural Product Sciences
JF - Natural Product Sciences
IS - 1
ER -
