Cytotoxic constituents from the stem bark of chisocheton pentandrus

Rurini Retnowati; Hermin Sulistyarti; Nikmatus Zahro Wahidah; Anisa Lailatusy Syarifah; Suprianto Salam; Nurlelasari; Agus Safari; Desi Harneti; Mulyadi Tanjung; Ace Tatang Hidayat; Rani Maharani; Unang Supratman; Yoshihito Shiono

doi:10.20307/nps.2021.27.1.18

Cytotoxic constituents from the stem bark of chisocheton pentandrus

Rurini Retnowati, Hermin Sulistyarti, Nikmatus Zahro Wahidah, Anisa Lailatusy Syarifah, Suprianto Salam, Nurlelasari, Agus Safari, Desi Harneti, Mulyadi Tanjung, Ace Tatang Hidayat, Rani Maharani, Unang Supratman, Yoshihito Shiono

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Eight cytotoxic constituents, consisting of six triterpenoids, cabralealactone (1), cabraleadiol (2), prototiamin A (3), 23-desmethyllimocin B (5), melianodiol (7) and indicalilacol (8) along with one limonoid, neemfruitins A (4) and one protolimonoid, protoxylocarpin G (6), were isolated from the extract of n-hexane of the stembark of Chisocheton pentandrus. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. These isolated compounds appear for the first time in the plant. Compounds 1-8 were evaluated for their cytotoxic effect against MCF-7 breast cancer lines in vitro. Among the isolated compounds, melianodiol (7) showed the strongest cytotoxic activity with IC₅₀ values of 16.8 μM.

Original language	English
Pages (from-to)	18-27
Number of pages	10
Journal	Natural Product Sciences
Volume	27
Issue number	1
DOIs	https://doi.org/10.20307/nps.2021.27.1.18
Publication status	Published - 2021

Keywords

-Chisocheton pentandrus
Limonoid
MCF-7 cell lines
Meliaceae
Triterpenoids

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.20307/nps.2021.27.1.18

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title = "Cytotoxic constituents from the stem bark of chisocheton pentandrus",

abstract = "Eight cytotoxic constituents, consisting of six triterpenoids, cabralealactone (1), cabraleadiol (2), prototiamin A (3), 23-desmethyllimocin B (5), melianodiol (7) and indicalilacol (8) along with one limonoid, neemfruitins A (4) and one protolimonoid, protoxylocarpin G (6), were isolated from the extract of n-hexane of the stembark of Chisocheton pentandrus. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. These isolated compounds appear for the first time in the plant. Compounds 1-8 were evaluated for their cytotoxic effect against MCF-7 breast cancer lines in vitro. Among the isolated compounds, melianodiol (7) showed the strongest cytotoxic activity with IC50 values of 16.8 μM.",

keywords = "-Chisocheton pentandrus, Limonoid, MCF-7 cell lines, Meliaceae, Triterpenoids",

author = "Rurini Retnowati and Hermin Sulistyarti and Wahidah, {Nikmatus Zahro} and Syarifah, {Anisa Lailatusy} and Suprianto Salam and Nurlelasari and Agus Safari and Desi Harneti and Mulyadi Tanjung and Hidayat, {Ace Tatang} and Rani Maharani and Unang Supratman and Yoshihito Shiono",

year = "2021",

doi = "10.20307/nps.2021.27.1.18",

language = "English",

volume = "27",

pages = "18--27",

journal = "Natural Product Sciences",

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T1 - Cytotoxic constituents from the stem bark of chisocheton pentandrus

AU - Retnowati, Rurini

AU - Sulistyarti, Hermin

AU - Wahidah, Nikmatus Zahro

AU - Syarifah, Anisa Lailatusy

AU - Salam, Suprianto

AU - Nurlelasari,

AU - Safari, Agus

AU - Harneti, Desi

AU - Tanjung, Mulyadi

AU - Hidayat, Ace Tatang

AU - Maharani, Rani

AU - Supratman, Unang

AU - Shiono, Yoshihito

PY - 2021

Y1 - 2021

N2 - Eight cytotoxic constituents, consisting of six triterpenoids, cabralealactone (1), cabraleadiol (2), prototiamin A (3), 23-desmethyllimocin B (5), melianodiol (7) and indicalilacol (8) along with one limonoid, neemfruitins A (4) and one protolimonoid, protoxylocarpin G (6), were isolated from the extract of n-hexane of the stembark of Chisocheton pentandrus. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. These isolated compounds appear for the first time in the plant. Compounds 1-8 were evaluated for their cytotoxic effect against MCF-7 breast cancer lines in vitro. Among the isolated compounds, melianodiol (7) showed the strongest cytotoxic activity with IC50 values of 16.8 μM.

AB - Eight cytotoxic constituents, consisting of six triterpenoids, cabralealactone (1), cabraleadiol (2), prototiamin A (3), 23-desmethyllimocin B (5), melianodiol (7) and indicalilacol (8) along with one limonoid, neemfruitins A (4) and one protolimonoid, protoxylocarpin G (6), were isolated from the extract of n-hexane of the stembark of Chisocheton pentandrus. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. These isolated compounds appear for the first time in the plant. Compounds 1-8 were evaluated for their cytotoxic effect against MCF-7 breast cancer lines in vitro. Among the isolated compounds, melianodiol (7) showed the strongest cytotoxic activity with IC50 values of 16.8 μM.

KW - -Chisocheton pentandrus

KW - Limonoid

KW - MCF-7 cell lines

KW - Meliaceae

KW - Triterpenoids

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U2 - 10.20307/nps.2021.27.1.18

DO - 10.20307/nps.2021.27.1.18

M3 - Article

AN - SCOPUS:85108533581

SN - 1226-3907

VL - 27

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EP - 27

JO - Natural Product Sciences

JF - Natural Product Sciences

IS - 1

ER -

Cytotoxic constituents from the stem bark of chisocheton pentandrus

Abstract

Keywords

UN SDGs

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