Cytotoxic Activity of Xanthones from the Stem Bark of Cratoxylum sumatranum

Shola Mardhiyyah, Mufidatuz Zakiyah, Erika D. Renata, Tjitjik S. Tjahjandarie, Unang Supratman, Rurini Retnowati, Ratih D. Saputri, Mulyadi Tanjung

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Two xanthones, gerontoxanthone I and macluraxanthone, were isolated from the stem bark of Cratoxylum sumatranum. Their structures were determined based on UV, HRESI-MS, 1D, and 2D NMR spectral data. Compounds 1 and 2 showed high activity against T47D cells with an IC50 of 1.10 and 1.60 μg/mL.

Original languageEnglish
Pages (from-to)3908-3910
Number of pages3
JournalTropical Journal of Natural Product Research
Volume7
Issue number9
DOIs
Publication statusPublished - 3 Oct 2023

Keywords

  • Cratoxylum sumatranum
  • T47D cells
  • cancer
  • gerontoxanthone I
  • macluraxanthone
  • xanthone

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