Cytotoxic Activity of Xanthones from the Stem Bark of Cratoxylum sumatranum

Shola Mardhiyyah; Mufidatuz Zakiyah; Erika D. Renata; Tjitjik S. Tjahjandarie; Unang Supratman; Rurini Retnowati; Ratih D. Saputri; Mulyadi Tanjung

doi:10.26538/tjnpr/v7i9.9

Cytotoxic Activity of Xanthones from the Stem Bark of Cratoxylum sumatranum

Shola Mardhiyyah, Mufidatuz Zakiyah, Erika D. Renata, Tjitjik S. Tjahjandarie, Unang Supratman, Rurini Retnowati, Ratih D. Saputri, Mulyadi Tanjung

Research output: Contribution to journal › Article › peer-review

Abstract

Two xanthones, gerontoxanthone I and macluraxanthone, were isolated from the stem bark of Cratoxylum sumatranum. Their structures were determined based on UV, HRESI-MS, 1D, and 2D NMR spectral data. Compounds 1 and 2 showed high activity against T47D cells with an IC₅₀ of 1.10 and 1.60 μg/mL.

Original language	English
Pages (from-to)	3908-3910
Number of pages	3
Journal	Tropical Journal of Natural Product Research
Volume	7
Issue number	9
DOIs	https://doi.org/10.26538/tjnpr/v7i9.9
Publication status	Published - 3 Oct 2023

Keywords

cancer
Cratoxylum sumatranum
gerontoxanthone I
macluraxanthone
T47D cells
xanthone

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.26538/tjnpr/v7i9.9

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title = "Cytotoxic Activity of Xanthones from the Stem Bark of Cratoxylum sumatranum",

abstract = "Two xanthones, gerontoxanthone I and macluraxanthone, were isolated from the stem bark of Cratoxylum sumatranum. Their structures were determined based on UV, HRESI-MS, 1D, and 2D NMR spectral data. Compounds 1 and 2 showed high activity against T47D cells with an IC50 of 1.10 and 1.60 μg/mL.",

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doi = "10.26538/tjnpr/v7i9.9",

language = "English",

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T1 - Cytotoxic Activity of Xanthones from the Stem Bark of Cratoxylum sumatranum

AU - Mardhiyyah, Shola

AU - Zakiyah, Mufidatuz

AU - Renata, Erika D.

AU - Tjahjandarie, Tjitjik S.

AU - Supratman, Unang

AU - Retnowati, Rurini

AU - Saputri, Ratih D.

AU - Tanjung, Mulyadi

PY - 2023/10/3

Y1 - 2023/10/3

N2 - Two xanthones, gerontoxanthone I and macluraxanthone, were isolated from the stem bark of Cratoxylum sumatranum. Their structures were determined based on UV, HRESI-MS, 1D, and 2D NMR spectral data. Compounds 1 and 2 showed high activity against T47D cells with an IC50 of 1.10 and 1.60 μg/mL.

AB - Two xanthones, gerontoxanthone I and macluraxanthone, were isolated from the stem bark of Cratoxylum sumatranum. Their structures were determined based on UV, HRESI-MS, 1D, and 2D NMR spectral data. Compounds 1 and 2 showed high activity against T47D cells with an IC50 of 1.10 and 1.60 μg/mL.

KW - cancer

KW - Cratoxylum sumatranum

KW - gerontoxanthone I

KW - macluraxanthone

KW - T47D cells

KW - xanthone

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U2 - 10.26538/tjnpr/v7i9.9

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M3 - Article

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SN - 2616-0684

VL - 7

SP - 3908

EP - 3910

JO - Tropical Journal of Natural Product Research

JF - Tropical Journal of Natural Product Research

IS - 9

ER -

Cytotoxic Activity of Xanthones from the Stem Bark of Cratoxylum sumatranum

Abstract

Keywords

UN SDGs

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