Coumarins and carbazole alkaloid from Clausena excavata roots and investigation of their α-glucosidase inhibitory activity

Tin M. Thant; Nanik S. Aminah; Alfinda N. Kristanti; Rico Ramadhan; Iffa H. Hasna; Hnin T. Aung; Yoshiaki Takaya

doi:10.26538/tjnpr/v4i8.2

Coumarins and carbazole alkaloid from Clausena excavata roots and investigation of their α-glucosidase inhibitory activity

Tin M. Thant, Nanik S. Aminah, Alfinda N. Kristanti, Rico Ramadhan, Iffa H. Hasna, Hnin T. Aung, Yoshiaki Takaya

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Clausena excavata Burm.f. has long been associated with medicinal benefits in folk medicine. This study isolated three known compounds which are two coumarins, umbelliferone (1), clausenidin (2) and one carbazole alkaloid, (2-hydroxy-3-formyl-7-methoxycarbazole (3) from the root of the plant. The compounds were characterized using their ¹H-NMR, ¹³C-NMR, COSY, HSQC and HMBC spectra and confirmed by literature data. The α-glucosidase inhibitory activity of the extract, fractions, compounds 2 and 3 were evaluated. The methanol extract exhibited higher inhibition against maltase α-glucosidase with IC₅₀ value 0.020 mg/mL than the n-hexane fraction which IC₅₀ value was 0.041 mg/mL.

Original language	English
Pages (from-to)	334-337
Number of pages	4
Journal	Tropical Journal of Natural Product Research
Volume	4
Issue number	8
DOIs	https://doi.org/10.26538/tjnpr/v4i8.2
Publication status	Published - Aug 2020

Keywords

2-hydroxy-3-formyl-7-methoxycarbazole
Antidiabetic
Clausena excavata
Clausenidin
Umbelliferone
α-glycosidase

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10.26538/tjnpr/v4i8.2

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title = "Coumarins and carbazole alkaloid from Clausena excavata roots and investigation of their α-glucosidase inhibitory activity",

abstract = "Clausena excavata Burm.f. has long been associated with medicinal benefits in folk medicine. This study isolated three known compounds which are two coumarins, umbelliferone (1), clausenidin (2) and one carbazole alkaloid, (2-hydroxy-3-formyl-7-methoxycarbazole (3) from the root of the plant. The compounds were characterized using their 1H-NMR, 13C-NMR, COSY, HSQC and HMBC spectra and confirmed by literature data. The α-glucosidase inhibitory activity of the extract, fractions, compounds 2 and 3 were evaluated. The methanol extract exhibited higher inhibition against maltase α-glucosidase with IC50 value 0.020 mg/mL than the n-hexane fraction which IC50 value was 0.041 mg/mL.",

keywords = "2-hydroxy-3-formyl-7-methoxycarbazole, Antidiabetic, Clausena excavata, Clausenidin, Umbelliferone, α-glycosidase",

author = "Thant, {Tin M.} and Aminah, {Nanik S.} and Kristanti, {Alfinda N.} and Rico Ramadhan and Hasna, {Iffa H.} and Aung, {Hnin T.} and Yoshiaki Takaya",

note = "Publisher Copyright: {\textcopyright} 2020 Thant et al.",

year = "2020",

month = aug,

doi = "10.26538/tjnpr/v4i8.2",

language = "English",

volume = "4",

pages = "334--337",

journal = "Tropical Journal of Natural Product Research",

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AU - Thant, Tin M.

AU - Aminah, Nanik S.

AU - Kristanti, Alfinda N.

AU - Ramadhan, Rico

AU - Hasna, Iffa H.

AU - Aung, Hnin T.

AU - Takaya, Yoshiaki

PY - 2020/8

Y1 - 2020/8

N2 - Clausena excavata Burm.f. has long been associated with medicinal benefits in folk medicine. This study isolated three known compounds which are two coumarins, umbelliferone (1), clausenidin (2) and one carbazole alkaloid, (2-hydroxy-3-formyl-7-methoxycarbazole (3) from the root of the plant. The compounds were characterized using their 1H-NMR, 13C-NMR, COSY, HSQC and HMBC spectra and confirmed by literature data. The α-glucosidase inhibitory activity of the extract, fractions, compounds 2 and 3 were evaluated. The methanol extract exhibited higher inhibition against maltase α-glucosidase with IC50 value 0.020 mg/mL than the n-hexane fraction which IC50 value was 0.041 mg/mL.

AB - Clausena excavata Burm.f. has long been associated with medicinal benefits in folk medicine. This study isolated three known compounds which are two coumarins, umbelliferone (1), clausenidin (2) and one carbazole alkaloid, (2-hydroxy-3-formyl-7-methoxycarbazole (3) from the root of the plant. The compounds were characterized using their 1H-NMR, 13C-NMR, COSY, HSQC and HMBC spectra and confirmed by literature data. The α-glucosidase inhibitory activity of the extract, fractions, compounds 2 and 3 were evaluated. The methanol extract exhibited higher inhibition against maltase α-glucosidase with IC50 value 0.020 mg/mL than the n-hexane fraction which IC50 value was 0.041 mg/mL.

KW - 2-hydroxy-3-formyl-7-methoxycarbazole

KW - Antidiabetic

KW - Clausena excavata

KW - Clausenidin

KW - Umbelliferone

KW - α-glycosidase

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U2 - 10.26538/tjnpr/v4i8.2

DO - 10.26538/tjnpr/v4i8.2

M3 - Article

AN - SCOPUS:85092434321

SN - 2616-0684

VL - 4

SP - 334

EP - 337

JO - Tropical Journal of Natural Product Research

JF - Tropical Journal of Natural Product Research

IS - 8

ER -

Coumarins and carbazole alkaloid from Clausena excavata roots and investigation of their α-glucosidase inhibitory activity

Abstract

Keywords

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