TY - JOUR
T1 - Correlation of tumor necrosis factor-α expression with pain level in degenerative lumbar canal stenosis patients
AU - Sakti, Yudha Mathan
AU - Magetsari, Rahadyan
AU - Hutahaean, David Yosua Parulian
AU - Sakadewa, Galih Prasetya
AU - Lasmana, Paramita Dyah
AU - Budhiparama, Nicolaas C.
AU - Dwianingsih, Ery Kus
N1 - Publisher Copyright:
© 2021 Yudha Mathan Sakti, Rahadyan Magetsari, David Yosua Parulian Hutahaean, Galih Prasetya Sakadewa, Paramita Dyah Lasmana, Nicolaas C. Budhiparama, Ery Kus Dwianingsih.
PY - 2021/12/26
Y1 - 2021/12/26
N2 - BACKGROUND: Pain in degenerative lumbar canal stenosis is caused by osteoarthritis of a facet joint and intervertebral disc degeneration. Some inflammatory mediators such as tumor necrosis factor (TNF)-α are present in degenerative lumbar canal stenosis. AIM: This study aimed to evaluate the correlation of pain and functional pre-operative scores with the expression of TNF-α in nucleus pulposus, annulus fibrosus, and facet joints. METHODS: Patients diagnosed with degenerative lumbar canal stenosis and planned for surgical treatment were included in this study. Patients with a history of fracture, neoplasm, and/or infection of the spine were excluded. Tissue samples were collected from the nucleus pulposus, annulus fibrosus, facet joint, flavum ligament, and paraspinal muscles of the spine during the surgery. TNF-α expression was examined semi-quantitively and correlated with the axial and radicular pain that was measured using the Visual Analog Scale (VAS) score. The result was then statistically analyzed. RESULTS: The expression of TNF-α in the paraspinal muscle was significantly higher compared to other locations. TNF-α expression in the facet joint group was significantly correlated with the intensity of low back pain measured by VAS score (r = 0.893, p < 0.001), and pre-operative functional outcome based on Oswestry Disability Index (ODI) (r = 0.948, p < 0.001). CONCLUSION: TNF-α expression, especially in the facet joint, is significantly associated with the pain intensity and pre-operative ODI that allow pain reduction with less invasive treatment in lumbar canal stenosis patients.
AB - BACKGROUND: Pain in degenerative lumbar canal stenosis is caused by osteoarthritis of a facet joint and intervertebral disc degeneration. Some inflammatory mediators such as tumor necrosis factor (TNF)-α are present in degenerative lumbar canal stenosis. AIM: This study aimed to evaluate the correlation of pain and functional pre-operative scores with the expression of TNF-α in nucleus pulposus, annulus fibrosus, and facet joints. METHODS: Patients diagnosed with degenerative lumbar canal stenosis and planned for surgical treatment were included in this study. Patients with a history of fracture, neoplasm, and/or infection of the spine were excluded. Tissue samples were collected from the nucleus pulposus, annulus fibrosus, facet joint, flavum ligament, and paraspinal muscles of the spine during the surgery. TNF-α expression was examined semi-quantitively and correlated with the axial and radicular pain that was measured using the Visual Analog Scale (VAS) score. The result was then statistically analyzed. RESULTS: The expression of TNF-α in the paraspinal muscle was significantly higher compared to other locations. TNF-α expression in the facet joint group was significantly correlated with the intensity of low back pain measured by VAS score (r = 0.893, p < 0.001), and pre-operative functional outcome based on Oswestry Disability Index (ODI) (r = 0.948, p < 0.001). CONCLUSION: TNF-α expression, especially in the facet joint, is significantly associated with the pain intensity and pre-operative ODI that allow pain reduction with less invasive treatment in lumbar canal stenosis patients.
KW - Degenerative lumbar canal stenosis
KW - Low back pain
KW - Tumor necrosis factor-α
UR - http://www.scopus.com/inward/record.url?scp=85117001490&partnerID=8YFLogxK
U2 - 10.3889/oamjms.2021.6708
DO - 10.3889/oamjms.2021.6708
M3 - Article
AN - SCOPUS:85117001490
SN - 1857-5749
VL - 9
SP - 1135
EP - 1139
JO - Open Access Macedonian Journal of Medical Sciences
JF - Open Access Macedonian Journal of Medical Sciences
ER -