Correlation of toluene safe concentration, malondialdehyde and glutathione levels in Osowilangun shoe home industry workers

Introduction: Toluene is the main organic solvent found in adhesives used for shoe production in Osowilangun Shoes Home Industry. Exposure to toluene that exceeds the threshold value can cause the emergence of free radicals which eventually increase the concentration of malondialdehyde and reduce the concentration of glutathione in the body. The purpose of this research is to study the safe concentration of toluene with levels of malondialdehyde and glutathione in Osowilangun shoe home industry workers. Methods: This is an observational study using cross sectional design and quantitative approaches. There are 25 people were taken as sample by using accidental sampling technique. Data analysis used Pearson correlation test. Result: The average safe concentration value in this study was 1.1088 mg / m3 with an average value of malondialdehyde of 7,784 MU and glutathione of 35,655 μg / L. Pearson correlation test showed the safe concentration of toluene and malondialdehyde level was p=0.685 (p> 0.05), with relationship between safe concentrations of toluene and glutathione was p = 0.808 (p <0.05). Conclusion: This study shows that there was no significant relationship between toluene safe concentration and levels of malondialdehyde and glutathione.