Abstract
Biomarkers of pro-inflammatory cytokines have been widely evaluated for their efficacy in the assessment of disease severity. The pleiotropic functions of Interleukin-6 (IL-6) allow it to induce the inflammatory responses acute phase. This study aimed to evaluate the correlation between PSI scores in patients with CAP and IL-6 levels. The study was a cross-sectional study. 26 pneumonia patients who met the inclusion and exclusion criteria were included in this study. IL-6 levels and PSI scores were calculated on the first day of patients treated. The mean±SD of PSI scores and IL-6 levels were 161.860±75.0042 and 88.58±25.511 respectively. The cut off point of IL-6 was 184.182 with 28% AUC (95% confidence interval of 10,4% — 45,6%) with p-value > 0.05. There was a significant correlation between the PSI score and interleukin-6 level with a strong positive correlation r = 0.673 (p-value < 0.05). PSI score and IL-6 level have a strong and significant positive correlation, these results suggest that IL-6 can be used as a biomarker to determine the severity of pneumonia inpatient.
Original language | English |
---|---|
Pages (from-to) | 58-62 |
Number of pages | 5 |
Journal | Journal of Advanced Pharmacy Education and Research |
Volume | 11 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2021 |
Keywords
- Community-Acquired Pneumonia
- Disease severity
- Interleukin-6
- PSI Scores