Correlation of MI/NAA with MMSE in Alzheimer's Dementia

Widiana Ferriastuti; Paulus Sugianto; Harianto Notopuro

doi:10.6890/IJGE.202304_17(2).0006

Correlation of MI/NAA with MMSE in Alzheimer's Dementia

Widiana Ferriastuti, Paulus Sugianto, Harianto Notopuro

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The delay and increase in the number of Alzheimer's dementia patients cause many impacts, both from increased morbidity and moral and material losses. Biomarkers such as brain imaging (magnetic resonance imaging (MRI) and positron emission tomography (PET) Scan) need to be done immediately in the diagnosis of suspected Alzheimer's dementia. This study aimed to analyze the relationship between the hippocampalmyo-inositol (MI)/ N-acetylaspartate (NAA) ratio and the severity of Mini-Mental State Examination (MMSE) in Alzheimer's dementia patients. Methods: MMSE and Hachinski scores were assessed by a neurologist, and the hippocampal mI/NAA ratio was calculated using MRI and MR spectroscopy. Results: The right hippocampal MI/NAA was significant with the incidence of Alzheimer's (p value = 0.018). Conclusion: There was a correlation between right MI/NAA and the severity of MMSE in Alzheimer's dementia patients.

Original language	English
Pages (from-to)	110-113
Number of pages	4
Journal	International Journal of Gerontology
Volume	17
Issue number	2
DOIs	https://doi.org/10.6890/IJGE.202304_17(2).0006
Publication status	Published - Apr 2023

Keywords

Alzheimer dementia
N-acetylas
hippocampal
myoinositol

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10.6890/IJGE.202304_17(2).0006

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title = "Correlation of MI/NAA with MMSE in Alzheimer's Dementia",

abstract = "Background: The delay and increase in the number of Alzheimer's dementia patients cause many impacts, both from increased morbidity and moral and material losses. Biomarkers such as brain imaging (magnetic resonance imaging (MRI) and positron emission tomography (PET) Scan) need to be done immediately in the diagnosis of suspected Alzheimer's dementia. This study aimed to analyze the relationship between the hippocampalmyo-inositol (MI)/ N-acetylaspartate (NAA) ratio and the severity of Mini-Mental State Examination (MMSE) in Alzheimer's dementia patients. Methods: MMSE and Hachinski scores were assessed by a neurologist, and the hippocampal mI/NAA ratio was calculated using MRI and MR spectroscopy. Results: The right hippocampal MI/NAA was significant with the incidence of Alzheimer's (p value = 0.018). Conclusion: There was a correlation between right MI/NAA and the severity of MMSE in Alzheimer's dementia patients.",

keywords = "Alzheimer dementia, N-acetylas, hippocampal, myoinositol",

author = "Widiana Ferriastuti and Paulus Sugianto and Harianto Notopuro",

note = "Publisher Copyright: {\textcopyright} 2023, Taiwan Society of Geriatric Emergency & Critical Care Medicine.",

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doi = "10.6890/IJGE.202304_17(2).0006",

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AU - Sugianto, Paulus

AU - Notopuro, Harianto

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N2 - Background: The delay and increase in the number of Alzheimer's dementia patients cause many impacts, both from increased morbidity and moral and material losses. Biomarkers such as brain imaging (magnetic resonance imaging (MRI) and positron emission tomography (PET) Scan) need to be done immediately in the diagnosis of suspected Alzheimer's dementia. This study aimed to analyze the relationship between the hippocampalmyo-inositol (MI)/ N-acetylaspartate (NAA) ratio and the severity of Mini-Mental State Examination (MMSE) in Alzheimer's dementia patients. Methods: MMSE and Hachinski scores were assessed by a neurologist, and the hippocampal mI/NAA ratio was calculated using MRI and MR spectroscopy. Results: The right hippocampal MI/NAA was significant with the incidence of Alzheimer's (p value = 0.018). Conclusion: There was a correlation between right MI/NAA and the severity of MMSE in Alzheimer's dementia patients.

AB - Background: The delay and increase in the number of Alzheimer's dementia patients cause many impacts, both from increased morbidity and moral and material losses. Biomarkers such as brain imaging (magnetic resonance imaging (MRI) and positron emission tomography (PET) Scan) need to be done immediately in the diagnosis of suspected Alzheimer's dementia. This study aimed to analyze the relationship between the hippocampalmyo-inositol (MI)/ N-acetylaspartate (NAA) ratio and the severity of Mini-Mental State Examination (MMSE) in Alzheimer's dementia patients. Methods: MMSE and Hachinski scores were assessed by a neurologist, and the hippocampal mI/NAA ratio was calculated using MRI and MR spectroscopy. Results: The right hippocampal MI/NAA was significant with the incidence of Alzheimer's (p value = 0.018). Conclusion: There was a correlation between right MI/NAA and the severity of MMSE in Alzheimer's dementia patients.

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KW - N-acetylas

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KW - myoinositol

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Correlation of MI/NAA with MMSE in Alzheimer's Dementia

Abstract

Keywords

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