TY - JOUR
T1 - Correlation of melanin content with collagen density in keloid patients
AU - Wihastyoko, Herman Y.L.
AU - Perdanakusuma, David S.
AU - Soeharto, Setyawati
AU - Widjajanto, Edi
AU - Handono, Kusworini
AU - Pardjianto, Bambang
N1 - Publisher Copyright:
© 2021 Herman Y. L. Wihastyoko, David S. Perdanakusuma, Setyawati Soeharto, Edi Widjajanto, Kusworini Handono, Bambang Pardjianto.
PY - 2021
Y1 - 2021
N2 - BACKGROUND: Keloid is a form of wound healing that results from fibrous tissue activity. It can develop beyond the boundaries of the original wound, extends into the dermis layer, and disrupting the appearance. Previously, no studies have revealed a correlation between melanin pigment and keloid. AIM: This research aimed to describe the correlation between melanin concentration and collagen deposition in keloid tissue. MATERIALS AND METHODS: A prospective study conducted through the application of a cross-sectional analytic survey method. The color of the skin was measured using a chromameter, and a histopathologic examination was performed on the skin surrounding the keloid, as well as the keloid tissue. Data were analyzed using a t-test, correlation, and linear regression statistics. RESULTS: The results showed a significant difference between melanin concentration and collagen deposition in the skin surrounding the keloid tissue. No significant difference was observed between melanin concentration in the surrounding skin of keloid and those in the keloid tissue, as well as collagen deposition. Meanwhile, the melanin concentration in the surrounding skin of keloid and keloid tissue had a significant relationship with fibrocytes number. CONCLUSION: There is a significant correlation between melanin concentrations and collagen density in the keloid tissue.
AB - BACKGROUND: Keloid is a form of wound healing that results from fibrous tissue activity. It can develop beyond the boundaries of the original wound, extends into the dermis layer, and disrupting the appearance. Previously, no studies have revealed a correlation between melanin pigment and keloid. AIM: This research aimed to describe the correlation between melanin concentration and collagen deposition in keloid tissue. MATERIALS AND METHODS: A prospective study conducted through the application of a cross-sectional analytic survey method. The color of the skin was measured using a chromameter, and a histopathologic examination was performed on the skin surrounding the keloid, as well as the keloid tissue. Data were analyzed using a t-test, correlation, and linear regression statistics. RESULTS: The results showed a significant difference between melanin concentration and collagen deposition in the skin surrounding the keloid tissue. No significant difference was observed between melanin concentration in the surrounding skin of keloid and those in the keloid tissue, as well as collagen deposition. Meanwhile, the melanin concentration in the surrounding skin of keloid and keloid tissue had a significant relationship with fibrocytes number. CONCLUSION: There is a significant correlation between melanin concentrations and collagen density in the keloid tissue.
KW - Collagen density
KW - Collagen deposition
KW - Keloid
KW - Melanin
KW - Skin
UR - http://www.scopus.com/inward/record.url?scp=85105928312&partnerID=8YFLogxK
U2 - 10.3889/oamjms.2021.6002
DO - 10.3889/oamjms.2021.6002
M3 - Article
AN - SCOPUS:85105928312
SN - 1857-5749
VL - 9
SP - 265
EP - 271
JO - Open Access Macedonian Journal of Medical Sciences
JF - Open Access Macedonian Journal of Medical Sciences
IS - B
ER -