TY - JOUR
T1 - Correlation of low CD4+ counts with high dental caries prevalence in children living with perinatal HIV/AIDS undergoing antiretroviral therapy
AU - Nugraha, Alexander Patera
AU - Mensana, Mario Powa
AU - Soebadi, Bagus
AU - Husada, Dominicus
AU - Triyono, Erwin Astha
AU - Prasetyo, Remita Adya
AU - Ernawati, Diah Savitri
N1 - Funding Information:
Association of Support to Oral Health Research-APESB. Acknowledgement: The authors would like to thank UPIPI, Tertiary General Hospital Doctor Soetomo and Faculty of Dental Medicine, Airlangga University, Surabaya, Indonesia, for supporting and helping our study.
Publisher Copyright:
© 2019, Association of Support to Oral Health Research (APESB). All rights reserved.
PY - 2019
Y1 - 2019
N2 - Objective: To investigate the correlation Cluster of Differentiation 4+ (CD4+) counts with a high prevalence of dental caries in Children Living with Perinatal Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (CLWPHA). Material and Methods: An analytical observational research with a cross-sectional design was conducted at Tertiary General Hospital, Surabaya, Indonesia. Randomized total sampling consisted of 29 CLWPHA 1-12 years old at outpatient ward Infectious Disease Intermediate Unit (UPIPI) Tertiary General Hospital Doctor Soetomo Surabaya. Demographic details and recent CD4+ counts obtained from medical records. Decayed, missing, filled teeth (dmft) in primary teeth and DMFT in permanent teeth index were used. Pearson's and Spearman's Correlation test (p<0.05) were performed. Results: Dental caries prevalence was 86.2%; meanwhile, the dmft/DMFT index score found were high (8.2/6.3). CD4+ count and caries showed significant correlation (r=-0.394, p<0.05). Tooth brushing frequency with caries showed a significant correlation (r=-0.419, p<0.05). Antiretroviral (ARV) therapy and caries showed an insignificant negative correlation (p<0.05). Conclusion: The high prevalence of dental caries in CLWPHA correlated with low CD4+ counts.
AB - Objective: To investigate the correlation Cluster of Differentiation 4+ (CD4+) counts with a high prevalence of dental caries in Children Living with Perinatal Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (CLWPHA). Material and Methods: An analytical observational research with a cross-sectional design was conducted at Tertiary General Hospital, Surabaya, Indonesia. Randomized total sampling consisted of 29 CLWPHA 1-12 years old at outpatient ward Infectious Disease Intermediate Unit (UPIPI) Tertiary General Hospital Doctor Soetomo Surabaya. Demographic details and recent CD4+ counts obtained from medical records. Decayed, missing, filled teeth (dmft) in primary teeth and DMFT in permanent teeth index were used. Pearson's and Spearman's Correlation test (p<0.05) were performed. Results: Dental caries prevalence was 86.2%; meanwhile, the dmft/DMFT index score found were high (8.2/6.3). CD4+ count and caries showed significant correlation (r=-0.394, p<0.05). Tooth brushing frequency with caries showed a significant correlation (r=-0.419, p<0.05). Antiretroviral (ARV) therapy and caries showed an insignificant negative correlation (p<0.05). Conclusion: The high prevalence of dental caries in CLWPHA correlated with low CD4+ counts.
KW - Acquired immunodeficiency syndrome
KW - Anti-retroviral agents
KW - Dental caries
UR - http://www.scopus.com/inward/record.url?scp=85070533671&partnerID=8YFLogxK
U2 - 10.4034/PBOCI.2019.191.119
DO - 10.4034/PBOCI.2019.191.119
M3 - Article
AN - SCOPUS:85070533671
SN - 1519-0501
VL - 19
JO - Pesquisa Brasileira em Odontopediatria e Clinica Integrada
JF - Pesquisa Brasileira em Odontopediatria e Clinica Integrada
IS - 1
M1 - e4819
ER -
