TY - JOUR
T1 - Correlation of Dynamic D-dimer Levels with Mortality in COVID-19 Patients with Type 2 Diabetes Mellitus
AU - Aminy, Rusdi Zakki
AU - Mudjanarko, Sony Wibisono
AU - Novida, Hermina
N1 - Funding Information:
The author is grateful for the assistance of academics who have written the quote above this article, and to the editor/publisher for every article and journal that becomes a source of literature.
Publisher Copyright:
© 2023 Academia Nacional de Medicina. All rights reserved.
PY - 2023/4
Y1 - 2023/4
N2 - Background: Hypercoagulation characterized by elevated D-dimer has been reported in COVID-19 patients. This condition is aggravated in Type 2 Diabetes Mellitus (T2DM) patients through various mechanisms. This study aimed to analyze the correlation of dynamic D-dimer levels with mortality in COVID-19 patients with T2DM. Methods: This retrospective study was conducted by taking data on adult COVID-19 patients with T2DM. D-dimer levels were checked serially on days 1, 4, 7, 10 and the last examination before patients died or were discharged. Correlation analysis between D-dimer levels and mortality was performed at each examination. Results: Of a total of 224 COVID-19 and T2DM patients, 26.3 % were deceased. Median D-dimer days 1, 4, 7, 10, and last examination in survived patients were 870, 960, 930, 885, 770 and deceased patients were 2 640, 2 620, 3 790, 3 440, 3 520, respectively. Patients who died had consistently higher D-dimer levels across all examinations (p<0.01). The results from ROC analysis to predict mortality showed that the highest AUCs obtained on day 10 and at the last examination were 0.87 and 0.92, respectively. Similar results were found in correlation analysis with contingency coefficients 0.447 and 0.523, respectively. Conclusion: Dynamic D-dimer correlates with mortality in COVID-19 patients with T2DM.
AB - Background: Hypercoagulation characterized by elevated D-dimer has been reported in COVID-19 patients. This condition is aggravated in Type 2 Diabetes Mellitus (T2DM) patients through various mechanisms. This study aimed to analyze the correlation of dynamic D-dimer levels with mortality in COVID-19 patients with T2DM. Methods: This retrospective study was conducted by taking data on adult COVID-19 patients with T2DM. D-dimer levels were checked serially on days 1, 4, 7, 10 and the last examination before patients died or were discharged. Correlation analysis between D-dimer levels and mortality was performed at each examination. Results: Of a total of 224 COVID-19 and T2DM patients, 26.3 % were deceased. Median D-dimer days 1, 4, 7, 10, and last examination in survived patients were 870, 960, 930, 885, 770 and deceased patients were 2 640, 2 620, 3 790, 3 440, 3 520, respectively. Patients who died had consistently higher D-dimer levels across all examinations (p<0.01). The results from ROC analysis to predict mortality showed that the highest AUCs obtained on day 10 and at the last examination were 0.87 and 0.92, respectively. Similar results were found in correlation analysis with contingency coefficients 0.447 and 0.523, respectively. Conclusion: Dynamic D-dimer correlates with mortality in COVID-19 patients with T2DM.
KW - COVID-19
KW - D-dimer
KW - Diabetes Mellitus
KW - Mortality
UR - http://www.scopus.com/inward/record.url?scp=85158114794&partnerID=8YFLogxK
U2 - 10.47307/GMC.2023.131.s2.5
DO - 10.47307/GMC.2023.131.s2.5
M3 - Article
AN - SCOPUS:85158114794
SN - 0367-4762
VL - 131
SP - S121-S129
JO - Gaceta Medica de Caracas
JF - Gaceta Medica de Caracas
ER -
