Correlation of aggressivity papilloma recurrent respiratory tract with human papillomavirus types 6 and 11

Background: Recurrent respiratory tract papilloma (PSPB) is a viral disease that correlated with an airway exophthalmia lesion. Papilloma is primarily caused by human papillomavirus (HPV) types 6 and 11 which are classified as low-risk HPV. Reports indicate that patients with the HPV-11 experience more aggressive course of the disease than HPV-6. Patients are often diagnosed at a younger age, the longer duration, require more frequent surgery and rare diseases of the disease when compared with those caused by HPV-6. Objectives: To investigate the correlation of aggressiveness of PSPB with HPV-6 and 11. Methods: Fifteen samples were conducted in the Outpatient Unit of Otorhinolaryngology and the Lotus Inpatient Installation of Dr. Soetomo General Hospital from December 2012 to March 2013 then determine the disease aggressiveness. PCR examination was done at the Tropical Disease Institute of Universitas Airlangga. Aggressive correlation of disease with HPV type was tested using Chi-Square. Results: Fifteen patients were enrolled that divided; the male was 10 and female was 5. The mean annual number of operations was 2.8 ± 1.27 and 9 patients reported more than 3 surgeries each year. 10 patients had distal papilloma and 11 patients had a history of tracheostomy. PSPB was found in 12 patients, HPV-11 was 9 patients and HPV-6 was 6 patients. Chi-square test results showed no significant results with p = 0.525. Conclusion: There was no correlation between PSPB aggression with HPV-6 and 11.