Correlation between intact parathyroid hormone levels and subperiosteal erosion toward phalanx manus and bone specific alkaline phosphatase level in pre-dialysis chronic kidney disease patients

There is high prevalence of bone disease due to abnormalities of parathyroid hormone (PTH) in chronic kidney disease (CKD). The study aims to determine correlation between iPTH and subperiosteal erosion and b-ALP toward phalanx manus in pre-dialysis CKD patients. The study was used analytical observational research with cross-sectional design. The samples were 60 pre-dialysis CKD patients. iPTH levels was measured using ECLIA method and subperiosteal erosion on phalanx manus was assessed using X-ray. In additions, b-ALP levels were measured using ELISA method. The correlation between iPTH with subperiosteal erosion and b-ALP were analysed using contingency coefficient test. Median of iPTH level was 102.19 pg/ml (12.46-477.30 pg/ml). Subperiosteal erosion was found in 76.7% pre-dialysis CKD patients. Meanwhile, median of b-ALP level was 29.88 ng/ml (12.79-110.38 ng/ml). The contingency coefficient test of iPTH with subperiosteal erosion found r=0.103 and p-value=0.727. Meanwhile, contingency coefficient test of iPTH with b-ALP showed r=0.167 and p-value=0.424.