Several factors such as host and viral factors can affect the progression of HIV/AIDS. This study aims to identify the correlation viral factors, especially the HIV-1 subtype with HIV/AIDS progression. Inpatient HIV/AIDS during the period March to September 2017 and willing to participate are included in the study. Historical data of disease and treatment was taken by medical record. Blood samples were amplified, sequenced and undergone phylogenetic analysis. Linear regression analysis was used to estimate beta coefficient (β) and 95%CI of HIV/AIDS progression (measured by the CD4 change rate, ΔCD4 cell count/time span in months).This study has 17 samples. The HIV-1 subtype was dominated by CRF01-AE (81.8%) followed by subtype B (18.2%). There was significant correlation between subtype HIV-1 (p = 0.04) and body mass index (p = 0.038) with HIV/AIDS clinical stage. Many factors were assumed to be correlated with increased rate of CD4, but we only subtype HIV-1 had a significant correlation (p = 0.024) with it. From multivariate analysis, we also found that subtype HIV-1 had a significant correlation (β = 0.788, 95%CI: 17.5-38.6, p = 0.004).
|Journal||IOP Conference Series: Earth and Environmental Science|
|Publication status||Published - 26 Mar 2018|
|Event||1st International Conference on Tropical Medicine and Infectious Diseases, ICTROMI 2017, in conjunction with The 23rd National Congress of the Indonesian Society of Tropical and Infectious Diseases Consultant, ISTIC 2017 and the 18th Annual Meeting of Internal Medicine Department, Faculty of Medicine, Universitas Sumatera - Medan, Indonesia|
Duration: 15 Nov 2017 → 18 Nov 2017