TY - JOUR
T1 - Correlation between DMF-T/def-t and the secretion of salivary hbd-1 in carious and non-carious group of children
AU - Indrawati, Retno
AU - Setiabudi, Hendrik
AU - Luthfi, Muhammad
AU - Nabella, Tamima Izzat
AU - Aulia, Dien Nisa
AU - Tantiana,
AU - Pradopo, Seno
N1 - Publisher Copyright:
© 2019, Indian Journal of Public Health Research and Development. All rights reserved.
PY - 2019/5
Y1 - 2019/5
N2 - Background: DMF-T/deft (Decay Missing Filled Teeth) is an index for assessing dental and oral health status, in this case, dental caries. Dental caries is a multifactorial disease with factors namely teeth and saliva, microorganisms, dietary, and time that affecting each other. Human Beta Defensins-1 (HBD-1) is an Antimicrobial Peptides (AMPs) that has a role as an adaptive immune system in oral health, is a factor that affects the susceptibility and development of dental caries that exhibits activity in Streptococcus mutans bacteria. Objective: To prove the relationship between DMF-T/deft and the levels of HBD-1 saliva secretion in the carious and non-carious groups of children. Method: This study was an observational analytic with cross-sectional study design, with the division of 3 groups namely; group 1 (DMF-T/deft = 0, caries-free), group 2 (DMF-T/deft = 1-3, low caries), and group 3 (DMF-T/deft > 6, high caries). Result: DMF-T/deft index (1,000) obtained HBD-1 concentration (-0.451). Low DMF-T/deft index has high HBD-1 concentration, whereas high DMF-T/deft index has low HBD-1 concentration. The value of p < (0.05) showed there was a significant correlation between the DMF-T/deft index with salivary HBD-1 concentrations.
AB - Background: DMF-T/deft (Decay Missing Filled Teeth) is an index for assessing dental and oral health status, in this case, dental caries. Dental caries is a multifactorial disease with factors namely teeth and saliva, microorganisms, dietary, and time that affecting each other. Human Beta Defensins-1 (HBD-1) is an Antimicrobial Peptides (AMPs) that has a role as an adaptive immune system in oral health, is a factor that affects the susceptibility and development of dental caries that exhibits activity in Streptococcus mutans bacteria. Objective: To prove the relationship between DMF-T/deft and the levels of HBD-1 saliva secretion in the carious and non-carious groups of children. Method: This study was an observational analytic with cross-sectional study design, with the division of 3 groups namely; group 1 (DMF-T/deft = 0, caries-free), group 2 (DMF-T/deft = 1-3, low caries), and group 3 (DMF-T/deft > 6, high caries). Result: DMF-T/deft index (1,000) obtained HBD-1 concentration (-0.451). Low DMF-T/deft index has high HBD-1 concentration, whereas high DMF-T/deft index has low HBD-1 concentration. The value of p < (0.05) showed there was a significant correlation between the DMF-T/deft index with salivary HBD-1 concentrations.
KW - DMF-T/def-t
KW - Dental Caries
KW - Human Beta Defensins-1
KW - Saliva
KW - Streptococcus mutans
UR - http://www.scopus.com/inward/record.url?scp=85092945961&partnerID=8YFLogxK
U2 - 10.5958/0976-5506.2019.01062.3
DO - 10.5958/0976-5506.2019.01062.3
M3 - Article
AN - SCOPUS:85092945961
SN - 0976-0245
VL - 10
SP - 545
EP - 549
JO - Indian Journal of Public Health Research and Development
JF - Indian Journal of Public Health Research and Development
IS - 5
ER -