Correlation between DMF-T/def-t and the secretion of salivary hbd-1 in carious and non-carious group of children

Retno Indrawati, Hendrik Setiabudi, Muhammad Luthfi, Tamima Izzat Nabella, Dien Nisa Aulia, Tantiana, Seno Pradopo

Research output: Contribution to journalArticlepeer-review


Background: DMF-T/deft (Decay Missing Filled Teeth) is an index for assessing dental and oral health status, in this case, dental caries. Dental caries is a multifactorial disease with factors namely teeth and saliva, microorganisms, dietary, and time that affecting each other. Human Beta Defensins-1 (HBD-1) is an Antimicrobial Peptides (AMPs) that has a role as an adaptive immune system in oral health, is a factor that affects the susceptibility and development of dental caries that exhibits activity in Streptococcus mutans bacteria. Objective: To prove the relationship between DMF-T/deft and the levels of HBD-1 saliva secretion in the carious and non-carious groups of children. Method: This study was an observational analytic with cross-sectional study design, with the division of 3 groups namely; group 1 (DMF-T/deft = 0, caries-free), group 2 (DMF-T/deft = 1-3, low caries), and group 3 (DMF-T/deft > 6, high caries). Result: DMF-T/deft index (1,000) obtained HBD-1 concentration (-0.451). Low DMF-T/deft index has high HBD-1 concentration, whereas high DMF-T/deft index has low HBD-1 concentration. The value of p < (0.05) showed there was a significant correlation between the DMF-T/deft index with salivary HBD-1 concentrations.

Original languageEnglish
Pages (from-to)545-549
Number of pages5
JournalIndian Journal of Public Health Research and Development
Issue number5
Publication statusPublished - May 2019


  • DMF-T/def-t
  • Dental Caries
  • Human Beta Defensins-1
  • Saliva
  • Streptococcus mutans


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