TY - JOUR
T1 - Correlation Between Apolipoprotein E and Recurrent Acute Coronary Syndrome
AU - Fuadi, Muhamad Robiul
AU - Nugraha, Jusak
AU - Suryawan, I. Gde Rurus
AU - Kahar, Hartono
AU - Aryati,
AU - Prabowo, Gwenny Ichsan
AU - Utomo, Budi
AU - I’tishom, Reny
N1 - Publisher Copyright:
© 2023, Iranian Heart Association. All rights reserved.
PY - 2023/10
Y1 - 2023/10
N2 - Background: Heart disease manifestation due to plaque disruption in the coronary arteries is acute coronary syndrome (ACS). Apolipoprotein-E (Apo-E) is a multifunctional protein with central roles in lipid transportation and metabolism. We analyzed the correlation between the Apo-E blood concentration and recurrent ACS. Methods: This cross-sectional study recruited 90 patients who visited the outpatient cardiology clinic at Airlangga University Hospital. The patients were divided into 3 groups: without ACS, single ACS, and recurrent ACS. The Apo-E blood concentration was measured using the enzyme-linked immunosorbent assay in the Tropical Disease Center of the Airlangga University Laboratory. Results: The median Apo-E concentration was 3.6 (1.32-14.9) µg/mL in the recurrent ACS group, 4.01 (2.61-18.54) µg/mL in the single ACS group, and 3.95 (1.19-43.51) µg/mL in the group without ACS. The Kruskal-Wallis test showed no differences in Apo-E between the groups. The χ2 test demonstrated no correlation concerning Apo-E between the single ACS and recurrent ACS groups. The Fisher exact analysis showed no correlation between the Apo-E concentration and dyslipidemia. Conclusions: Our results showed no correlation between the Apo-E concentration and recurrent ACS.
AB - Background: Heart disease manifestation due to plaque disruption in the coronary arteries is acute coronary syndrome (ACS). Apolipoprotein-E (Apo-E) is a multifunctional protein with central roles in lipid transportation and metabolism. We analyzed the correlation between the Apo-E blood concentration and recurrent ACS. Methods: This cross-sectional study recruited 90 patients who visited the outpatient cardiology clinic at Airlangga University Hospital. The patients were divided into 3 groups: without ACS, single ACS, and recurrent ACS. The Apo-E blood concentration was measured using the enzyme-linked immunosorbent assay in the Tropical Disease Center of the Airlangga University Laboratory. Results: The median Apo-E concentration was 3.6 (1.32-14.9) µg/mL in the recurrent ACS group, 4.01 (2.61-18.54) µg/mL in the single ACS group, and 3.95 (1.19-43.51) µg/mL in the group without ACS. The Kruskal-Wallis test showed no differences in Apo-E between the groups. The χ2 test demonstrated no correlation concerning Apo-E between the single ACS and recurrent ACS groups. The Fisher exact analysis showed no correlation between the Apo-E concentration and dyslipidemia. Conclusions: Our results showed no correlation between the Apo-E concentration and recurrent ACS.
KW - Apo-E
KW - Cardiovascular disease
KW - Dyslipidemia
KW - Risk factor
UR - http://www.scopus.com/inward/record.url?scp=85174245880&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85174245880
SN - 1735-7306
VL - 24
SP - 63
EP - 69
JO - Iranian Heart Journal
JF - Iranian Heart Journal
IS - 4
ER -