TY - JOUR
T1 - Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis
T2 - Breaking the Bridge
AU - Effendi, Wiwin Is
AU - Nagano, Tatsuya
N1 - Funding Information:
We would like to express our gratitude to the Department of Pulmonology and Respiratory Medicine of Universitas Airlangga. The illustrated figures were created with Biorender.com.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/6/1
Y1 - 2022/6/1
N2 - CTGF is upregulated in patients with idiopathic pulmonary fibrosis (IPF), characterized by the deposition of a pathological extracellular matrix (ECM). Additionally, many omics studies confirmed that aberrant cellular senescence-associated mitochondria dysfunction and metabolic reprogramming had been identified in different IPF lung cells (alveolar epithelial cells, alveolar endothelial cells, fibroblasts, and macrophages). Here, we reviewed the role of the CTGF in IPF lung cells to mediate anomalous senescence-related metabolic mechanisms that support the fibrotic environment in IPF.
AB - CTGF is upregulated in patients with idiopathic pulmonary fibrosis (IPF), characterized by the deposition of a pathological extracellular matrix (ECM). Additionally, many omics studies confirmed that aberrant cellular senescence-associated mitochondria dysfunction and metabolic reprogramming had been identified in different IPF lung cells (alveolar epithelial cells, alveolar endothelial cells, fibroblasts, and macrophages). Here, we reviewed the role of the CTGF in IPF lung cells to mediate anomalous senescence-related metabolic mechanisms that support the fibrotic environment in IPF.
KW - CTGF
KW - chronic respiratory diseases
KW - idiopathic pulmonary fibrosis
KW - metabolic dysregulation
KW - mitochondria dysfunction
KW - pro-fibrotic
KW - senescence
UR - http://www.scopus.com/inward/record.url?scp=85130772361&partnerID=8YFLogxK
U2 - 10.3390/ijms23116064
DO - 10.3390/ijms23116064
M3 - Review article
C2 - 35682743
AN - SCOPUS:85130772361
SN - 1661-6596
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 11
M1 - 6064
ER -
