Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge

Wiwin Is Effendi, Tatsuya Nagano

Research output: Contribution to journalReview articlepeer-review

26 Citations (Scopus)

Abstract

CTGF is upregulated in patients with idiopathic pulmonary fibrosis (IPF), characterized by the deposition of a pathological extracellular matrix (ECM). Additionally, many omics studies confirmed that aberrant cellular senescence-associated mitochondria dysfunction and metabolic reprogramming had been identified in different IPF lung cells (alveolar epithelial cells, alveolar endothelial cells, fibroblasts, and macrophages). Here, we reviewed the role of the CTGF in IPF lung cells to mediate anomalous senescence-related metabolic mechanisms that support the fibrotic environment in IPF.

Original languageEnglish
Article number6064
JournalInternational Journal of Molecular Sciences
Volume23
Issue number11
DOIs
Publication statusPublished - 1 Jun 2022

Keywords

  • CTGF
  • chronic respiratory diseases
  • idiopathic pulmonary fibrosis
  • metabolic dysregulation
  • mitochondria dysfunction
  • pro-fibrotic
  • senescence

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