Concurrent antipsychotic use in older adults treated with antidepressants in Asia

Min Dong; Liang Nan Zeng; Qinge Zhang; Gabor S. Ungvari; Chee H. Ng; Helen F.K. Chiu; Tian Mei Si; Kang Sim; Ajit Avasthi; Sandeep Grover; Mian Yoon Chong; Kok Yoon Chee; Shigenobu Kanba; Min Soo Lee; Shu Yu Yang; Pichet Udomratn; Roy A. Kallivayalil; Andi J. Tanra; Margarita M. Maramis; Winston W. Shen; Norman Sartorius; Rathi Mahendran; Chay Hoon Tan; Naotaka Shinfuku; Yu Tao Xiang

doi:10.1111/psyg.12416

Concurrent antipsychotic use in older adults treated with antidepressants in Asia

Min Dong, Liang Nan Zeng, Qinge Zhang, Gabor S. Ungvari, Chee H. Ng, Helen F.K. Chiu, Tian Mei Si, Kang Sim, Ajit Avasthi, Sandeep Grover, Mian Yoon Chong, Kok Yoon Chee, Shigenobu Kanba, Min Soo Lee, Shu Yu Yang, Pichet Udomratn, Roy A. Kallivayalil, Andi J. Tanra, Margarita M. Maramis, Winston W. ShenNorman Sartorius, Rathi Mahendran, Chay Hoon Tan, Naotaka Shinfuku, Yu Tao Xiang

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Aim: Depressive disorders are common in old age. Antipsychotics (APs) are often used as an adjunctive treatment with antidepressants (ADs) in this population but its patterns of use in Asia are not known. This study explored the rate of combination of APs and ADs in older adult psychiatric patients in Asia. Methods: This is a secondary analysis of the database of a multicentre study which recorded participants’ basic demographical and clinical data in standardised format in 10 Asian countries and territories. The data were analysed using univariate and multivariate logistic regression analyses. Results: A total of 955 older adult psychiatric in- and outpatients were included in this study. The proportion of concurrent AP and AD use was 32.0%, ranging from 23.3% in Korea to 44.0% in Taiwan. Multivariate logistic regression analysis found that younger age, inpatient status and diagnosis of schizophrenia, anxiety and other mental disorders were significantly related to a higher proportion of concurrent use of APs and ADs. Conclusion: Around a third of older adult psychiatric patients had concurrent AP and AD use in the Asian countries/regions surveyed. Considering the uncertain effectiveness and questionable safety of the AP and AD combination in this patient population, such should be cautiously used.

Original language	English
Pages (from-to)	333-339
Number of pages	7
Journal	Psychogeriatrics
Volume	19
Issue number	4
DOIs	https://doi.org/10.1111/psyg.12416
Publication status	Published - Jul 2019

Keywords

adjunctive treatment
antidepressants
antipsychotics
Asia
older adults

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/psyg.12416

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Dong, M., Zeng, L. N., Zhang, Q., Ungvari, G. S., Ng, C. H., Chiu, H. F. K., Si, T. M., Sim, K., Avasthi, A., Grover, S., Chong, M. Y., Chee, K. Y., Kanba, S., Lee, M. S., Yang, S. Y., Udomratn, P., Kallivayalil, R. A., Tanra, A. J., Maramis, M. M., ... Xiang, Y. T. (2019). Concurrent antipsychotic use in older adults treated with antidepressants in Asia. Psychogeriatrics, 19(4), 333-339. https://doi.org/10.1111/psyg.12416

@article{50298cddf7f8469ca156acd848f9e8a4,

title = "Concurrent antipsychotic use in older adults treated with antidepressants in Asia",

abstract = "Aim: Depressive disorders are common in old age. Antipsychotics (APs) are often used as an adjunctive treatment with antidepressants (ADs) in this population but its patterns of use in Asia are not known. This study explored the rate of combination of APs and ADs in older adult psychiatric patients in Asia. Methods: This is a secondary analysis of the database of a multicentre study which recorded participants{\textquoteright} basic demographical and clinical data in standardised format in 10 Asian countries and territories. The data were analysed using univariate and multivariate logistic regression analyses. Results: A total of 955 older adult psychiatric in- and outpatients were included in this study. The proportion of concurrent AP and AD use was 32.0%, ranging from 23.3% in Korea to 44.0% in Taiwan. Multivariate logistic regression analysis found that younger age, inpatient status and diagnosis of schizophrenia, anxiety and other mental disorders were significantly related to a higher proportion of concurrent use of APs and ADs. Conclusion: Around a third of older adult psychiatric patients had concurrent AP and AD use in the Asian countries/regions surveyed. Considering the uncertain effectiveness and questionable safety of the AP and AD combination in this patient population, such should be cautiously used.",

keywords = "adjunctive treatment, antidepressants, antipsychotics, Asia, older adults",

author = "Min Dong and Zeng, {Liang Nan} and Qinge Zhang and Ungvari, {Gabor S.} and Ng, {Chee H.} and Chiu, {Helen F.K.} and Si, {Tian Mei} and Kang Sim and Ajit Avasthi and Sandeep Grover and Chong, {Mian Yoon} and Chee, {Kok Yoon} and Shigenobu Kanba and Lee, {Min Soo} and Yang, {Shu Yu} and Pichet Udomratn and Kallivayalil, {Roy A.} and Tanra, {Andi J.} and Maramis, {Margarita M.} and Shen, {Winston W.} and Norman Sartorius and Rathi Mahendran and Tan, {Chay Hoon} and Naotaka Shinfuku and Xiang, {Yu Tao}",

note = "Funding Information: This work was supported by the Taipei City Hospital (10201-62-077), Taipei, Taiwan and the University of Macau (MYRG2015-00230-FHS; MYRG2016-00005-FHS). The authors would like to thank all clinicians involved in the REAP-AD project. Publisher Copyright: {\textcopyright} 2019 Japanese Psychogeriatric Society",

year = "2019",

month = jul,

doi = "10.1111/psyg.12416",

language = "English",

volume = "19",

pages = "333--339",

journal = "Psychogeriatrics",

issn = "1346-3500",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "4",

}

Dong, M, Zeng, LN, Zhang, Q, Ungvari, GS, Ng, CH, Chiu, HFK, Si, TM, Sim, K, Avasthi, A, Grover, S, Chong, MY, Chee, KY, Kanba, S, Lee, MS, Yang, SY, Udomratn, P, Kallivayalil, RA, Tanra, AJ, Maramis, MM, Shen, WW, Sartorius, N, Mahendran, R, Tan, CH, Shinfuku, N & Xiang, YT 2019, 'Concurrent antipsychotic use in older adults treated with antidepressants in Asia', Psychogeriatrics, vol. 19, no. 4, pp. 333-339. https://doi.org/10.1111/psyg.12416

TY - JOUR

T1 - Concurrent antipsychotic use in older adults treated with antidepressants in Asia

AU - Dong, Min

AU - Zeng, Liang Nan

AU - Zhang, Qinge

AU - Ungvari, Gabor S.

AU - Ng, Chee H.

AU - Chiu, Helen F.K.

AU - Si, Tian Mei

AU - Sim, Kang

AU - Avasthi, Ajit

AU - Grover, Sandeep

AU - Chong, Mian Yoon

AU - Chee, Kok Yoon

AU - Kanba, Shigenobu

AU - Lee, Min Soo

AU - Yang, Shu Yu

AU - Udomratn, Pichet

AU - Kallivayalil, Roy A.

AU - Tanra, Andi J.

AU - Maramis, Margarita M.

AU - Shen, Winston W.

AU - Sartorius, Norman

AU - Mahendran, Rathi

AU - Tan, Chay Hoon

AU - Shinfuku, Naotaka

AU - Xiang, Yu Tao

N1 - Funding Information: This work was supported by the Taipei City Hospital (10201-62-077), Taipei, Taiwan and the University of Macau (MYRG2015-00230-FHS; MYRG2016-00005-FHS). The authors would like to thank all clinicians involved in the REAP-AD project. Publisher Copyright: © 2019 Japanese Psychogeriatric Society

PY - 2019/7

Y1 - 2019/7

N2 - Aim: Depressive disorders are common in old age. Antipsychotics (APs) are often used as an adjunctive treatment with antidepressants (ADs) in this population but its patterns of use in Asia are not known. This study explored the rate of combination of APs and ADs in older adult psychiatric patients in Asia. Methods: This is a secondary analysis of the database of a multicentre study which recorded participants’ basic demographical and clinical data in standardised format in 10 Asian countries and territories. The data were analysed using univariate and multivariate logistic regression analyses. Results: A total of 955 older adult psychiatric in- and outpatients were included in this study. The proportion of concurrent AP and AD use was 32.0%, ranging from 23.3% in Korea to 44.0% in Taiwan. Multivariate logistic regression analysis found that younger age, inpatient status and diagnosis of schizophrenia, anxiety and other mental disorders were significantly related to a higher proportion of concurrent use of APs and ADs. Conclusion: Around a third of older adult psychiatric patients had concurrent AP and AD use in the Asian countries/regions surveyed. Considering the uncertain effectiveness and questionable safety of the AP and AD combination in this patient population, such should be cautiously used.

AB - Aim: Depressive disorders are common in old age. Antipsychotics (APs) are often used as an adjunctive treatment with antidepressants (ADs) in this population but its patterns of use in Asia are not known. This study explored the rate of combination of APs and ADs in older adult psychiatric patients in Asia. Methods: This is a secondary analysis of the database of a multicentre study which recorded participants’ basic demographical and clinical data in standardised format in 10 Asian countries and territories. The data were analysed using univariate and multivariate logistic regression analyses. Results: A total of 955 older adult psychiatric in- and outpatients were included in this study. The proportion of concurrent AP and AD use was 32.0%, ranging from 23.3% in Korea to 44.0% in Taiwan. Multivariate logistic regression analysis found that younger age, inpatient status and diagnosis of schizophrenia, anxiety and other mental disorders were significantly related to a higher proportion of concurrent use of APs and ADs. Conclusion: Around a third of older adult psychiatric patients had concurrent AP and AD use in the Asian countries/regions surveyed. Considering the uncertain effectiveness and questionable safety of the AP and AD combination in this patient population, such should be cautiously used.

KW - adjunctive treatment

KW - antidepressants

KW - antipsychotics

KW - Asia

KW - older adults

UR - http://www.scopus.com/inward/record.url?scp=85061295881&partnerID=8YFLogxK

U2 - 10.1111/psyg.12416

DO - 10.1111/psyg.12416

M3 - Article

C2 - 30734411

AN - SCOPUS:85061295881

SN - 1346-3500

VL - 19

SP - 333

EP - 339

JO - Psychogeriatrics

JF - Psychogeriatrics

IS - 4

ER -

Concurrent antipsychotic use in older adults treated with antidepressants in Asia

Abstract

Keywords

UN SDGs

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