Computer Aided Drug Discovery Utilization in Conservative Dentistry

Computer aided drugs discovery or in silico design is bioinformatics’ contribution that supports pharmacy, medical and dentistry fields. It creates innovation in the search, design and optimization of new drug candidates. The method minimizes the use of animal models and in vitro assay laboratory work, which are very time and resources consuming processes. Even though it has big advantages, it has not been utilized frequently in conservative dentistry fields. Researches using CADD approaches in conservative dentistry shown in the reviews, used Structure-based design and Ligand-based design, both are two methods to predict compound-protein interaction. Utilized as genome identification of Streptococcus mutans, CADD can differ the genome from other bacteria and gives confirmation to polymerase chain reaction examination. CADD also beneficial to predict pharmacokinetics of drug candidates. This method exhibits great prediction in screening active compounds that have inhibition action in bacterial growth and adhesion on dental plaque. CADD approach has been used in conservative dentistry and showed great predictions to minimize numbers of trials in laboratory works. Expansion of application might boost drugs design projects in conservative dentistry.