Computational approach in searching for dual action multitarget inhibitors for osteosarcoma

Keyphrases

• Computational Approach 100%
• Dual Action 100%
• Osteosarcoma 100%
• Dual-target Inhibitor 100%
• Raloxifene 80%
• Simvastatin 80%
• Molecular Docking 20%
• Bone Remodeling 20%
• Osteogenic 20%
• Hydrogen Bonds (H-bonds) 20%
• Alendronate 20%
• Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) 20%
• Interaction Type 20%
• Binding Affinity 20%
• Ascorbic Acid 20%
• AutoDock Vina 20%
• Ligand Preparation 20%
• Membrane Protein 20%
• Protein Preparation 20%
• Osteogenic Properties 20%
• Molecular Docking Studies 20%
• Vascular Endothelial Growth Factor Receptor (VEGFR) 20%
• Risedronate 20%
• Zoledronic Acid 20%
• Binding Activity 20%
• Fibroblast Growth Factor Receptor 1 (FGFR1) 20%
• Platelet-derived Growth Factor Receptor (PDGFR) 20%
• Acid Ascorbic 20%
• Primary Malignant Bone Tumor 20%
• β-glycerophosphate 20%
• Hydrophobically 20%
• Ibandronate 20%

Biochemistry, Genetics and Molecular Biology

• Simvastatin 100%
• Dexamethasone 100%
• Raloxifene 100%
• Binding Affinity 50%
• Docking (Molecular) 50%
• Bone Remodeling 25%
• Ascorbic Acid 25%
• AutoDock 25%
• Platelet Derived Growth Factor Receptor Alpha 25%
• Fibroblast Growth Factor Receptor 1 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Osteosarcoma 100%
• Dexamethasone 80%
• Raloxifene 80%
• Simvastatin 80%
• Ascorbic Acid 20%
• Alendronic Acid 20%
• Bone Cancer 20%
• Risedronic Acid 20%
• Zoledronic Acid 20%
• Ibandronic Acid 20%
• Glycerophosphate 20%
• Fibroblast Growth Factor Receptor 1 20%