Comparison of vitamin D levels in sacrouterine ligament tissue and blood among women with and without uterine prolapse

This analytical observational study, designed as a case-control study, aims to compare Vitamin D levels in sacrouterine ligament tissue and blood between women with and without uterine prolapse undergoing surgery at Dr. Soetomo Hospital and Airlangga University Hospital. The findings reveal that vitamin D levels in sacrouterine ligament tissue are generally higher than in blood across both groups. The mean vitamin D level in ligament tissue across all subjects was 31.65 ± 10.81 ng/mL, whereas the mean blood vitamin D level was 15.65 ± 7.99 ng/mL. This difference suggests a potential mechanism of local accumulation or regulation of vitamin D within the sacrouterine ligament. Despite vitamin D’s known role in calcium metabolism and connective tissue health, this study found no significant relationship between vitamin D levels and the occurrence of uterine prolapse. Other factors, such as age and childbirth history, may have a greater influence on uterine prolapse development.