TY - JOUR
T1 - Comparison of thickness, biomechanical characteristics, and absorption capacity of decellularized freeze-dried amnion membrane from human and bovine sources
AU - Roychan, Maghrizal
AU - Suroto, Heri
AU - Wardhana, Teddy Heri
AU - Chilmi, Mohammad Zaim
AU - Widhiyanto, Lukas
AU - Utomo, Budi
N1 - Publisher Copyright:
© 2025 by SPC (Sami Publishing Company).
PY - 2025/1
Y1 - 2025/1
N2 - Open and extensive wounds are significantly detrimental to patients. Amnion membranes as a biomaterial for wound dressings have advantages compared to skin grafts. Bovine sources do not have ethical problems and more abundant. The aim of this study was to compare the thickness, tensile and elastic properties, and absorption capacity of bovine and human amnion membrane preparations available from the tissue bank at Dr. Soetomo General Academic Hospital. This study is an analytical, experimental design with a post-test-only control group, with sample size of 12 for each group. It compared Freeze-dried Amnion Membranes from Bovine and Human sources in thickness in mm using a coating thickness gauge, tensile strength in N/mm2 using the material testing machine, and absorption capacity in g/cm2 using scale. The thickness of bovine amnion membranes is 0.614 ± 0.11 mm and the human source is 0.205 ± 0.04 mm. The tensile strength studies showed the bovine source has a result of 25.48 ± 3.79 N/mm² and the human source has 14.88 ± 5.63 N/mm². The absorption capacity studies showed the bovine source has a result of 0.054 ± 0.009 g/cm², while the human source showed 0.043 ± 0.0098 g/cm². This study shwed that the bovine amnion membrane is thicker, has higher tensile strength, and more water absorption power than the human amnion membrane. Freeze-dried bovine amnion membrane provides better characteristics than human sources in terms of thickness, tensile strength, and absorption capacity. Bovine amnion membrane can be a better alternative for wound dressings.
AB - Open and extensive wounds are significantly detrimental to patients. Amnion membranes as a biomaterial for wound dressings have advantages compared to skin grafts. Bovine sources do not have ethical problems and more abundant. The aim of this study was to compare the thickness, tensile and elastic properties, and absorption capacity of bovine and human amnion membrane preparations available from the tissue bank at Dr. Soetomo General Academic Hospital. This study is an analytical, experimental design with a post-test-only control group, with sample size of 12 for each group. It compared Freeze-dried Amnion Membranes from Bovine and Human sources in thickness in mm using a coating thickness gauge, tensile strength in N/mm2 using the material testing machine, and absorption capacity in g/cm2 using scale. The thickness of bovine amnion membranes is 0.614 ± 0.11 mm and the human source is 0.205 ± 0.04 mm. The tensile strength studies showed the bovine source has a result of 25.48 ± 3.79 N/mm² and the human source has 14.88 ± 5.63 N/mm². The absorption capacity studies showed the bovine source has a result of 0.054 ± 0.009 g/cm², while the human source showed 0.043 ± 0.0098 g/cm². This study shwed that the bovine amnion membrane is thicker, has higher tensile strength, and more water absorption power than the human amnion membrane. Freeze-dried bovine amnion membrane provides better characteristics than human sources in terms of thickness, tensile strength, and absorption capacity. Bovine amnion membrane can be a better alternative for wound dressings.
KW - absorption capacity
KW - Bovine amnion membrane
KW - human amnion membrane
KW - swelling
KW - tensile strength
KW - wound dressing
UR - http://www.scopus.com/inward/record.url?scp=85202551223&partnerID=8YFLogxK
U2 - 10.48309/jmpcr.2025.457748.1248
DO - 10.48309/jmpcr.2025.457748.1248
M3 - Article
AN - SCOPUS:85202551223
SN - 2981-0221
VL - 7
SP - 161
EP - 171
JO - Journal of Medicinal and Pharmaceutical Chemistry Research
JF - Journal of Medicinal and Pharmaceutical Chemistry Research
IS - 2
ER -