TY - JOUR
T1 - Comparison of serum tumor necrosis factor, superoxide dismutase, and heat shock protein-70 levels during cardiopulmonary bypass and ischemia reperfusion injury after cardiopulmonary bypass in cardiac surgery
AU - Husain, Teuku Aswin
AU - Setiawan, P.
AU - Sembiring, Yan Efrata
AU - Budiono,
N1 - Publisher Copyright:
© 2021, The Indonesian Foundation of Critical Care Medicine. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Objective: This study aims to determine the comparison between tumor necrosis factor (TNF)-a, superoxide dismutase (SOD), and heat shock protein (HSP)-70 levels during cardiopulmonary bypass (CPB) and ischemia reperfusion injury after cardiopulmonary bypass. Design: This study was an analytical observational study with a cross sectional design. Setting: This study was conducted at Dr. Soetomo General Hospital Surabaya. The period of study was from April 2020 to September 2020. Patients and participants: Population of study was all adult patients who underwent on pump cardiac surgery. Study samples were patients who were included in inclusion criterion. Patients’ characteristics were presented as frequency and percentage. Measurement and results: All interval data with normal distribution were analyzed using T-pair test. Statistical test using the Wilcoxon signed-ranks test (two-tailed) was performed to determine comparison of TNF-a, SOD, and HSP-70 levels during CPB and after CPB. There were 30 subjects who underwent adult cardiac surgeries including coronary artery bypass graft (CABG), valve, and double procedures. According to statistical test, there was a significant increase of TNF-a, SOD, and HSP-70 levels during cardiopulmonary bypass compared to after cardiopulmonary bypass with p-value <0.05. Pearson correlation test was performed to determine the correlation between elevated levels of TNF-a, SOD, HSP-70 during CPB impact. There was significant correlation between TNF-a and SOD (p<0.05), and also between SOD and HSP-70 (p<0.05). Conclusion: Our study showed that CPB impact significantly contributes to the increase of TNF-a, SOD, and HSP-70 levels compared to after CPB in patient undergoing on pump cardiac surgeries.
AB - Objective: This study aims to determine the comparison between tumor necrosis factor (TNF)-a, superoxide dismutase (SOD), and heat shock protein (HSP)-70 levels during cardiopulmonary bypass (CPB) and ischemia reperfusion injury after cardiopulmonary bypass. Design: This study was an analytical observational study with a cross sectional design. Setting: This study was conducted at Dr. Soetomo General Hospital Surabaya. The period of study was from April 2020 to September 2020. Patients and participants: Population of study was all adult patients who underwent on pump cardiac surgery. Study samples were patients who were included in inclusion criterion. Patients’ characteristics were presented as frequency and percentage. Measurement and results: All interval data with normal distribution were analyzed using T-pair test. Statistical test using the Wilcoxon signed-ranks test (two-tailed) was performed to determine comparison of TNF-a, SOD, and HSP-70 levels during CPB and after CPB. There were 30 subjects who underwent adult cardiac surgeries including coronary artery bypass graft (CABG), valve, and double procedures. According to statistical test, there was a significant increase of TNF-a, SOD, and HSP-70 levels during cardiopulmonary bypass compared to after cardiopulmonary bypass with p-value <0.05. Pearson correlation test was performed to determine the correlation between elevated levels of TNF-a, SOD, HSP-70 during CPB impact. There was significant correlation between TNF-a and SOD (p<0.05), and also between SOD and HSP-70 (p<0.05). Conclusion: Our study showed that CPB impact significantly contributes to the increase of TNF-a, SOD, and HSP-70 levels compared to after CPB in patient undergoing on pump cardiac surgeries.
KW - Cardiopulmonary bypass
KW - HSP-70
KW - SOD
KW - TNF-a
UR - http://www.scopus.com/inward/record.url?scp=85112111182&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85112111182
SN - 1410-7767
VL - 2021
SP - 181
EP - 189
JO - Critical Care and Shock
JF - Critical Care and Shock
IS - July
ER -