Background: Uncontrolled asthma symptoms will exacerbate asthma. Aminofilin is now rarely used as asthma medication abroad because it shows major side effects, unlike in Indonesia, which is still widely used with relatively rare side effects events. Aminophylline have relatively more affordable price compared to salbutamol, the first-line option in the management of asthma exacerbations requirements. Both of these drugs have a risk of causing electrolyte disturbances, which could endanger the patients. Considering the individual drug side effects, so it important to study the safety of the medicine to ascertain whether there are differences in the incidence of electrolyte disturbances by both drugs. Objective: The main objective of this study was to determine differences in the incidence of electrolyte disturbances in patients with asthma exacerbations prescribed with aminophylline and salbutamol at a hospital in Surabaya. Method: This study design is a cross-sectional study of inpatient adult asthma exacerbations in emergency room (ER), using two groups, namely the group receiving intravenous aminophylline therapy (n = 22), and the group receiving nebulized salbutamol therapy (n = 21). Result: There is no significant difference between in intravenous aminophylline anda nebulized salbutamol group. And there is no significant difference in sodium (p>0,866) and potassium (p>0,470) level in blood as a respon to the asthma exacerbations treatment by intravenous aminophylline compared to nebulized salbutamol. Conclusion: Although there was no significant difference in the incidence of electrolyte disturbances in both drugs, but close monitoring is still needed to prevent any side effects incident.
|Number of pages||8|
|Journal||International Journal of Pharmaceutical and Clinical Research|
|Publication status||Published - 1 Apr 2016|
- Asthma exacerbations
- Electrolyte disturbance