Comparative analysis of low-intensity resistance training with blood flow restriction and moderate-intensity resistance training on insulin-like growth Factor-1 serum levels in elderly women

As individuals age, there is a decline in muscle mass in Insulin-like growth factor-1 (IGF-1), which contributes to skeletal muscle loss and an increased risk of falls. Previous research showed that low-intensity resistance training with blood flow restriction (LI-BFR) has significantly improved IGF-1 levels. LI-BFR can serve as an alternative to increase muscle strength and size, which is comparable to moderate-intensity resistance training (MI-RT). This study aimed to analyze the comparison effect of LI-BFR and MI-RT on IGF-1 levels in elderly women. The study included a sample of 22 elderly women who met the inclusion criteria and were randomly assigned to two groups. The MI-RT group underwent moderate-intensity training (≥40-60%1RM), while the LI-BFR group performed low-intensity exercises (20-30%1RM) with blood flow restriction applied to the lower extremities at a pressure of 50 mmHg or 40% Arterial Occlusion Pressure (AOP). The intervention period was 6 weeks, with serum IGF-1 levels being assessed prior to and following the intervention. The results revealed no substantial difference in IGF-1 levels in MI-RT (p=0.19), LI-BFR (p=0.85), and delta between both groups (p=0.6). Low-Intensity Resistance Training with Blood Flow Restriction is as effective as Moderate-Intensity Training in elderly women.