Background: Previous research focused on in vitro and animal study of stem cell metabolites formula derived from the placenta for skin regeneration. Objective: This further study is a clinical trial to evaluate the effectiveness of stem cell metabolites formula in skin regeneration. Methods: Priorly, subjects' facial conditions were examined and recorded using Janus skin analyzer to observe marks and blemishes present on their skin. Stem cell metabolites were applied on the face twice a day, day and night, with singleuse doses of three pumps. We evaluated before and after stem cell metabolites application using Janus over the period six months, with three times repeated evaluation every two months. The Janus evaluation results are Spot, Pore, Roughness, Wrinkle, UV Acne, UV Spot, and UV Moisture. Results: The percentage of spot, pore, roughness, wrinkle, UV acne, and UV spots were noticeably reduced. Meanwhile, the percentage of UV moisture increased in almost all subjects who were evaluated for six months. From a qualitative aspect, 90% of subjects are satisfied with the results of the application of stem cell metabolites. The subjects felt that facial wrinkles had reduced, the face was smoother and supple, and reduction in dark pigmentation. Conclusion: It can be concluded that stem cell metabolites are useful in face skin regeneration.

Original languageEnglish
Pages (from-to)768-771
Number of pages4
JournalSystematic Reviews in Pharmacy
Issue number5
Publication statusPublished - 2020


  • Clinical outcomes
  • Formula
  • Placenta
  • Skin regeneration
  • Stem cell metabolites


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