TY - JOUR
T1 - Clinical characteristics and surgical outcomes of cardiac myxoma
T2 - A meta-analysis of worldwide experience
AU - Oktaviono, Yudi Her
AU - Saputra, Pandit Bagus Tri
AU - Arnindita, Jannatin Nisa
AU - Afgriyuspita, Lelyana Sih
AU - Kurniawan, Roy Bagus
AU - Pasahari, Diar
AU - Milla, Clonia
AU - Wungu, Citrawati Dyah Kencono
AU - Susilo, Hendri
AU - Multazam, Chaq El Chaq Zamzam
AU - Alkaff, Firas Farisi
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2024/2
Y1 - 2024/2
N2 - Cardiac myxoma is the most common primary cardiac tumor. However, existing literature mainly consists of single-center experiences with limited subjects. This systematic review aimed to provide data on clinical characteristics and surgical outcomes of cardiac myxoma. We performed a thorough literature search on May 23, 2023 on PubMed, ProQuest, ScienceDirect, Scopus, and Web of Science. The inclusion criteria were English full-text, observational studies, and included >20 subjects. From the search, 112 studies with a total of 8150 patients were included in the analysis. The mean age was 51 years (95 % confidence interval [95%CI] = 49.1–52.3), and the majority were females (64.3 % [95 % CI = 62.8–65.8 %]). The most common clinical manifestation was cardiovascular symptoms. Echocardiography can diagnose almost all cases (98.1 % [95 % CI = 95.8–99.6 %]). Cardiac myxoma was mostly prevalent in left atrium (85.3 % [95%CI = 83.3–87 %]) and predominantly with pedunculated morphology (75.6 % [95%CI = 64.1–84.3 %]). Post-tumor excision outcomes were excellent, with an early mortality of 1.27 % (95 % CI = 0.8–1.8 %), late mortality rate of 4.7 (95 % CI = 2.5–7.4) per 1000 person-years, and recurrence rate at 0.5 (95 % CI = 0.0–1.1) per 1000 person-years. Tumor excision is warranted in a timely manner once the cardiac myxoma diagnosis is established.
AB - Cardiac myxoma is the most common primary cardiac tumor. However, existing literature mainly consists of single-center experiences with limited subjects. This systematic review aimed to provide data on clinical characteristics and surgical outcomes of cardiac myxoma. We performed a thorough literature search on May 23, 2023 on PubMed, ProQuest, ScienceDirect, Scopus, and Web of Science. The inclusion criteria were English full-text, observational studies, and included >20 subjects. From the search, 112 studies with a total of 8150 patients were included in the analysis. The mean age was 51 years (95 % confidence interval [95%CI] = 49.1–52.3), and the majority were females (64.3 % [95 % CI = 62.8–65.8 %]). The most common clinical manifestation was cardiovascular symptoms. Echocardiography can diagnose almost all cases (98.1 % [95 % CI = 95.8–99.6 %]). Cardiac myxoma was mostly prevalent in left atrium (85.3 % [95%CI = 83.3–87 %]) and predominantly with pedunculated morphology (75.6 % [95%CI = 64.1–84.3 %]). Post-tumor excision outcomes were excellent, with an early mortality of 1.27 % (95 % CI = 0.8–1.8 %), late mortality rate of 4.7 (95 % CI = 2.5–7.4) per 1000 person-years, and recurrence rate at 0.5 (95 % CI = 0.0–1.1) per 1000 person-years. Tumor excision is warranted in a timely manner once the cardiac myxoma diagnosis is established.
KW - Cancer
KW - Cardiac Tumor
KW - Epidemiology
KW - Mortality
KW - Myxoma
KW - Recurrence
UR - http://www.scopus.com/inward/record.url?scp=85182558575&partnerID=8YFLogxK
U2 - 10.1016/j.ejso.2023.107940
DO - 10.1016/j.ejso.2023.107940
M3 - Review article
C2 - 38219702
AN - SCOPUS:85182558575
SN - 0748-7983
VL - 50
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
IS - 2
M1 - 107940
ER -
