Abstract

Everyday stress is unpredictable and comes in many different forms. The person is constantly exposed to stress because they cannot handle it. Chronic stress results from this illness. Chronic stress can affect changes in the body's standard mechanisms, including body weight modulated by the circadian cycle. Due to the fact that each person's response to stress is unique, stressful situations might result in two different variations in body weight. The purpose of this study is tobserve the effect of the CUMS on weight changes in Rattus novergicus through the circadian cycle mechanism. 16 chronic stress models of the Rattus norergicus were split into control and treatment groups. The chronic stress was provided using the Chronic Unpredictable Mild Stress (CUMS) approach. The control group did not receive any treatment but was still given maintenance such as providing food, drink and measuring their body weight every day. While the treatment group received CUMs for 20 days. Every morning before the stressor exposure, body weight was recorded. And the measurement of corticosterone levels using the Enzyme-Linked Immunoassay (ELISA) method with the Duplo technique. Before termination, blood is taken at the heart. Corticosterone levels varied across the groups (p = 0.032). The study's changes in body weight (p = 0.00) revealed a difference between the control and treatment groups, with the treatment group's weight being -11.15 ± 7.91. Chronic stress can alter how the body normally functions, mainly how the circadian cycle regulates body weight. Since each person's response to stress is unique, stressful situations might result in two different variations in body weight.

Original languageEnglish
Pages (from-to)469-474
Number of pages6
JournalInternational Journal of Disabilities Sports and Health Sciences
Volume7
Issue number2
DOIs
Publication statusPublished - 25 Mar 2024

Keywords

  • Chronic Unpredictable Mild Stress
  • Circadian Cyle
  • Weight Changes

Fingerprint

Dive into the research topics of 'Chronic Unpredictable Mild Stress Affects Weight Changes Through Circadian Cycle Mechanism'. Together they form a unique fingerprint.

Cite this