Chronic kidney disease-mineral and bone disorders laboratory profiles in chronic haemodialysis patients

Chronic kidney disease- mineral and bone disorder (CKD-MKD) has describe more clinical syndrome which develops as systemic disorder of mineral and bone metabolism as result of CKD. The study aims to determine chronic kidney disease-mineral and bone disorder laboratory profile in chronic haemodialysis patients in Dr. Soetomo Hospital, Surabaya. The demographic and laboratory data (calcium, phosphorus, intact parathyroid hormone and alkali phosphatase) were collected from 150 chronic haemodialysis patients. The study was used descriptive research using cross-sectional design. This study had been implemented in Dr. Soetomo Hospital and conducted between March and April 2007. The samples had been selected by consecutive technique method. The blood serum for calcium, phosphorus and total alkaline phosphatase and albumin were analysed. The result found intact parathyroid hormone level (iPTH) decreased with age. The phosphorus level was observed lower in respondents with diabetes mellitus (DM) than non-DM but higher with longer haemodialysis duration. The corrected calcium met the optimal range of 8.4 mg/ dl to 9.5 mg/dl and 38% of respondents had optimal of CaxP product less than 55mg2/dl2. There were 27.3% of respondents had optimal iPTH level with range of 150 pg/ml and 300 pg/ml. The intact parathyroid hormone level in diabetes mellitus (DM) tended lower than non-DM and increased by longer haemodialysis duration. Low turnover prediction (iPTH< 60pg/ml) was 11.3% and high turnover prediction (iPTH> 200 pg/ml with total alkali phosphatase >207 IU/L) was 22%.