Chrobisiamone A, a new bischromone from Cassia siamea and a biomimetic transformation of 5-acetonyl-7-hydroxy-2-methylchromone into cassiarin A

Shiori Oshimi, Yuichiro Tomizawa, Yusuke Hirasawa, Toshio Honda, Wiwied Ekasari, Aty Widyawaruyanti, Marcellino Rudyanto, Gunawan Indrayanto, Noor Cholies Zaini, Hiroshi Morita

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

A new bischromone, chrobisiamone A (1) with an antiplasmodial activity has been isolated from the leaves of Cassia siamea and the structure was elucidated by 2D NMR analysis. Cyclization of 5-acetonyl-7-hydroxy-2-methylchromone (2) in the presence of ammonium acetate resulted in generation of cassiarin A (3) with an unprecedented tricyclic skeleton, supporting a biogenetic pathway proposed for 3.

Original languageEnglish
Pages (from-to)3761-3763
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number13
DOIs
Publication statusPublished - 1 Jul 2008

Keywords

  • Antiplasmodial activity
  • Biomimetic transformation
  • Bischromone
  • Cassia siamea
  • Chrobisiamone A

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