Cholesterol implications on coconut liposomes encapsulation of beta-carotene and vitamin C

Dwi Hudiyanti, Siti Aminah, Yuanita Hikmahwati, Parsaoran Siahaan

Research output: Contribution to journalConference articlepeer-review

12 Citations (Scopus)

Abstract

The implication of cholesterol on coconut liposomes encapsulation of beta-carotene and vitamin C was investigated through their encapsulation efficiency (EE) and partition coefficient (log P). In sole encapsulation the presence of cholesterol up to 40% showed a decline in beta-carotene's EE while for vitamin C the EE was improved. The presence of cholesterol affects co-encapsulation both vitamin C and beta-carotene. The beta-carotene EE decreases as the cholesterol increases but vitamin C achieves optimum value at 90.05% in 20% cholesterol. The log P value of coconut phospholipids, vitamin C, cholesterol and beta-carotene were 4.8711.2;-1.91; 7.11; and 11.12 respectively. The encapsulation efficiency and partition coefficient reveals that co-encapsulation of Vitamin C and beta-carotene in coconut liposomes is influenced by cholesterol because of their unique molecular lipophilicity.

Original languageEnglish
Article number012037
JournalIOP Conference Series: Materials Science and Engineering
Volume509
Issue number1
DOIs
Publication statusPublished - 3 May 2019
Externally publishedYes
Event13th Joint Conference on Chemistry, JCC 2018 - Semarang, Indonesia
Duration: 7 Sept 20188 Sept 2018

Keywords

  • Cocos nucifera L
  • Liposomes
  • Marvin Sketch
  • beta-carotene
  • cholesterol
  • encapsulation
  • hydrophobicity
  • membrane
  • partition coefficient
  • vitamin C

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