Chemical composition and anticancer activity of macaranga hosei leaves

Eva Marliana; Winni Astuti; Khemasili Kosala; Rita Hairani; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung

doi:10.14233/ajchem.2018.21004

Chemical composition and anticancer activity of macaranga hosei leaves

Eva Marliana, Winni Astuti, Khemasili Kosala, Rita Hairani, Tjitjik Srie Tjahjandarie, Mulyadi Tanjung

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The anticancer activity of methanolic extract and ethyl acetate fraction of Macaranga hosei leaves against HeLa cell lines were evaluated by [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay. Both extracts displayed anticancer activity with IC50 values of 36.18 and 7.01 µM, respectively, which can be suggested that M. hosei is a great potential source of anticancer agents. In addition, two isoprenylated flavanones, 4'-O-methyl-8-isoprenyl eriodictyol (1) and 6-isoprenyl eriodictyol (2) have been isolated from ethyl acetate fraction. The structures of both compounds have been elucidated based on their spectroscopic data, including 1D and 2D NMR spectra.

Original language	English
Pages (from-to)	795-798
Number of pages	4
Journal	Asian Journal of Chemistry
Volume	30
Issue number	4
DOIs	https://doi.org/10.14233/ajchem.2018.21004
Publication status	Published - 2018

Keywords

Anticancer
Flavanones
Isoprenylated
MTT Assay
Macaranga hosei

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.14233/ajchem.2018.21004

Cite this

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title = "Chemical composition and anticancer activity of macaranga hosei leaves",

abstract = "The anticancer activity of methanolic extract and ethyl acetate fraction of Macaranga hosei leaves against HeLa cell lines were evaluated by [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay. Both extracts displayed anticancer activity with IC50 values of 36.18 and 7.01 µM, respectively, which can be suggested that M. hosei is a great potential source of anticancer agents. In addition, two isoprenylated flavanones, 4'-O-methyl-8-isoprenyl eriodictyol (1) and 6-isoprenyl eriodictyol (2) have been isolated from ethyl acetate fraction. The structures of both compounds have been elucidated based on their spectroscopic data, including 1D and 2D NMR spectra.",

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AU - Marliana, Eva

AU - Astuti, Winni

AU - Kosala, Khemasili

AU - Hairani, Rita

AU - Tjahjandarie, Tjitjik Srie

AU - Tanjung, Mulyadi

PY - 2018

Y1 - 2018

N2 - The anticancer activity of methanolic extract and ethyl acetate fraction of Macaranga hosei leaves against HeLa cell lines were evaluated by [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay. Both extracts displayed anticancer activity with IC50 values of 36.18 and 7.01 µM, respectively, which can be suggested that M. hosei is a great potential source of anticancer agents. In addition, two isoprenylated flavanones, 4'-O-methyl-8-isoprenyl eriodictyol (1) and 6-isoprenyl eriodictyol (2) have been isolated from ethyl acetate fraction. The structures of both compounds have been elucidated based on their spectroscopic data, including 1D and 2D NMR spectra.

AB - The anticancer activity of methanolic extract and ethyl acetate fraction of Macaranga hosei leaves against HeLa cell lines were evaluated by [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay. Both extracts displayed anticancer activity with IC50 values of 36.18 and 7.01 µM, respectively, which can be suggested that M. hosei is a great potential source of anticancer agents. In addition, two isoprenylated flavanones, 4'-O-methyl-8-isoprenyl eriodictyol (1) and 6-isoprenyl eriodictyol (2) have been isolated from ethyl acetate fraction. The structures of both compounds have been elucidated based on their spectroscopic data, including 1D and 2D NMR spectra.

KW - Anticancer

KW - Flavanones

KW - Isoprenylated

KW - MTT Assay

KW - Macaranga hosei

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Chemical composition and anticancer activity of macaranga hosei leaves

Abstract

Keywords

UN SDGs

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