Characterization of HIV-1 CRF01_AE env Genes Derived from Recently Infected Indonesian Individuals

Maho Sasaki, Tomohiro Kotaki, Siti Qamariyah Khairunisa, Shingo Tachibana, Youdiil Ophinni, Yoshitake Hayashi, Nasronudin, Masanori Kameoka

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1 Citation (Scopus)


To eradicate human immunodeficiency virus type 1 (HIV-1) infection, a comprehensive strategy including preventive vaccine development is needed. Envelope glycoproteins (Env) play a central role in viral infection and are the major targets of humoral immune responses. Therefore, Env is a candidate vaccine antigen, and its characterization is necessary for vaccine development. The characterization of the transmitted/founder (T/F; i.e., recently infected) virus that is responsible for the establishment of infection and induction of primary anti-HIV-1 immune responses is important. We herein established HIV-1 env clones derived from recently infected Indonesian individuals. All env genes were classified into CRF01-AE. The immunological characterization of env clones was performed by neutralization tests using a series of broadly neutralizing antibodies. The present study is the first to immunologically characterize the CRF01-AE T/F virus circulating in Indonesia.

Original languageEnglish
Pages (from-to)242-247
Number of pages6
JournalAIDS Research and Human Retroviruses
Issue number3
Publication statusPublished - Mar 2020


  • CRF01-AE
  • HIV-1 envelope glycoproteins
  • Indonesia
  • Recent infection
  • Transmitted/founder virus


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