TY - JOUR
T1 - Characterization, Formulation, and Evaluation of Tablet Containing Johar Leaves (Cassia siamea Lamk.) Extract with Hydroxypropyl Methylcellulose (HPMC) as Tablet Binder
AU - Fristiohady, Adryan
AU - Suryani, Suryani
AU - Fitrawan, La Ode Muhammad
AU - Andriani, Rina
AU - Aspadiah, Vica
AU - Saripuddin, Saripuddin
AU - Purnama, La Ode Muhammad Julian
AU - Hamsidi, Rini
AU - Indalifiany, Astrid
N1 - Funding Information:
The authors thank the Universitas Halu Oleo for the financial support
Publisher Copyright:
© 2020 by the authors.
PY - 2021/6/30
Y1 - 2021/6/30
N2 - Utilization of Johar leaves (Cassia siamea Lamk.) as an herbal remedy requires development into tablet formulation. The selection of binders in the tablet formulation is a strategy for producing quality tablets. Thus, this study aims to formulate Johar leaves extract by using HPMC in various concentrations as the binder (2%, 3%, and 4%) into tablets and evaluate their physical properties. Johar leaves extract is characterized and formulated into tablets in 3 various concentrations of HPMC as the binder. The physical properties of the tablets were evaluated. Johar leaves extract was gum-like, blackish brown, Johar leaves-specific odor, and bitter taste; moisture content, ash content, solubility in water, and solubility in ethanol were 5.2; 2; 11.7; and 38.3%, respectively. The organoleptic evaluation showed the round and flat texture of the tablet, and still experiencing mottling in all formulation; deviation of tablet in all formulas were 11.83; 18.33; and 18.56 mg, respectively; in the uniformity of tablet size showed that the diameter of the tablet were 1.48, 1.51, and 1.48 times of tablet thickness; tablet hardness all formulas were similar, i.e., 20.39 kg.cm-2, and lastly, the disintegration time of formulas were 10, 9, and 12 minutes, respectively. In conclusion, tablets have good physical properties by using various concentrations of HPMC as a binder.
AB - Utilization of Johar leaves (Cassia siamea Lamk.) as an herbal remedy requires development into tablet formulation. The selection of binders in the tablet formulation is a strategy for producing quality tablets. Thus, this study aims to formulate Johar leaves extract by using HPMC in various concentrations as the binder (2%, 3%, and 4%) into tablets and evaluate their physical properties. Johar leaves extract is characterized and formulated into tablets in 3 various concentrations of HPMC as the binder. The physical properties of the tablets were evaluated. Johar leaves extract was gum-like, blackish brown, Johar leaves-specific odor, and bitter taste; moisture content, ash content, solubility in water, and solubility in ethanol were 5.2; 2; 11.7; and 38.3%, respectively. The organoleptic evaluation showed the round and flat texture of the tablet, and still experiencing mottling in all formulation; deviation of tablet in all formulas were 11.83; 18.33; and 18.56 mg, respectively; in the uniformity of tablet size showed that the diameter of the tablet were 1.48, 1.51, and 1.48 times of tablet thickness; tablet hardness all formulas were similar, i.e., 20.39 kg.cm-2, and lastly, the disintegration time of formulas were 10, 9, and 12 minutes, respectively. In conclusion, tablets have good physical properties by using various concentrations of HPMC as a binder.
KW - HPMC
KW - Johar leaves (Cassia siamea Lamk.)
KW - tablet formulation
UR - http://www.scopus.com/inward/record.url?scp=85151900186&partnerID=8YFLogxK
U2 - 10.33263/LIANBS102.20702077
DO - 10.33263/LIANBS102.20702077
M3 - Article
AN - SCOPUS:85151900186
SN - 2284-6808
VL - 10
SP - 2070
EP - 2077
JO - Letters in Applied NanoBioScience
JF - Letters in Applied NanoBioScience
IS - 2
ER -