TY - JOUR
T1 - Characterization and Phytochemical Screening of Meniran (Phyllanthus niruri Linn) Extract's Nanoparticles Used Ball Mill Method
AU - Sabdoningrum, Emy Koestanti
AU - Hidanah, Sri
AU - Chusniati, Sri
AU - Soeharsono, null
N1 - Funding Information:
We thank Universitas Airlangga, Indonesia for the financial support.
Publisher Copyright:
© 2021 Phcogj.Com.
PY - 2021/12
Y1 - 2021/12
N2 - The aim of this study was to study the characterization and phytochemical screening of meniran (Phyllanthus niruri linn) extract's nanoparticles used ball mill method. The effect of herbal products would be maximized, a formulation that able to increase solubility, stability, bioavailability, and a targeted system was needed so the use of simplicia would be more effective. One of alternative solutions to this problem was to make the preparation of meniran extract in the form of nanoparticles. Nanoparticles made it easier for extract to be absorbed in blood plasma and were more effective in achieving the target drug itself. The manufacture of meniran nanoparticles used ball mill method. Then, meniran extract nanoparticles characterization and phytochemical screening were carried out. Meniran (Phyllanthus niruri Linn) extract nanoparticle characterization consisted of size, used Particle Size Analyzer (PSA), and morphology, used Scaning Electron Microscope (SEM). Phytochemical screening of meniran extract nanoparticles used qualitative screening by reagent test. The results showed that the meniran extract nanoparticles produced an average size of 192.6 nm. The averange shape of particle was imperfectly amorphous and the dominant composition was Carbon (C). Phytochemical screening showed the content of flavonoids, tannins, saponins, terpenoids and alkaloids.
AB - The aim of this study was to study the characterization and phytochemical screening of meniran (Phyllanthus niruri linn) extract's nanoparticles used ball mill method. The effect of herbal products would be maximized, a formulation that able to increase solubility, stability, bioavailability, and a targeted system was needed so the use of simplicia would be more effective. One of alternative solutions to this problem was to make the preparation of meniran extract in the form of nanoparticles. Nanoparticles made it easier for extract to be absorbed in blood plasma and were more effective in achieving the target drug itself. The manufacture of meniran nanoparticles used ball mill method. Then, meniran extract nanoparticles characterization and phytochemical screening were carried out. Meniran (Phyllanthus niruri Linn) extract nanoparticle characterization consisted of size, used Particle Size Analyzer (PSA), and morphology, used Scaning Electron Microscope (SEM). Phytochemical screening of meniran extract nanoparticles used qualitative screening by reagent test. The results showed that the meniran extract nanoparticles produced an average size of 192.6 nm. The averange shape of particle was imperfectly amorphous and the dominant composition was Carbon (C). Phytochemical screening showed the content of flavonoids, tannins, saponins, terpenoids and alkaloids.
KW - Biological production
KW - Nanoparticle
KW - Phyllanthus niruri
KW - Phytochemical compound
UR - http://www.scopus.com/inward/record.url?scp=85122975310&partnerID=8YFLogxK
U2 - 10.5530/pj.2021.13.200
DO - 10.5530/pj.2021.13.200
M3 - Article
AN - SCOPUS:85122975310
SN - 0975-3575
VL - 13
SP - 1568
EP - 1572
JO - Pharmacognosy Journal
JF - Pharmacognosy Journal
IS - 6
ER -