Characteristics of granulosa cell tumor at Dr. Soetomo general hospital from 2014 to 2019

Eko Santoso, Brahmana Askandar Tjokroprawiro, Ni Nyoman Ratih Pradnyani

Research output: Contribution to journalArticlepeer-review


Objectives: The aim of the present study was to investigate tumor characteristics, treatment, recurrence, and prognosis in both Granulosa Cell Tumor types. Materials and Methods: A retrospective review study of 38 patients in a single institute; We identified patients with GCTs diagnosed between 2014 and 2019 in the Regional General Dr. Soetomo Hospital. Surgical outcome, pathological findings and follow-up data were analyzed. Statistical analyses were conducted using Fisher exact test and Kaplan-Meier survival curves and compared with the log-rank test. Results: The prevalence of AGCT subtypes as the most common type occurring in 97% of cases. The median age at diagnosis among patients with AGCT is 47.5 years (range 41-59), and most women are premenopausal and multiparous. In our literature review Stage 1 disease is 76% with Overall Survival (OS) for 5years is 89.7%. FIGO stage and adjuvant therapy was not shown a positive correlation with recurrency (p >0.05). Rate of recurrence in AGCT is reported to be as high as 5.26%. Conclusions: GCT is a rare low malignant tumor, majority of patients present with early-stage disease and generally have a favorable prognosis. Stage is not considered as the most important prognostic factor. The role of adjuvant chemotherapy treatment is debatable as it was not shown to reduce recurrence rates. Long-term surveillance including routine clinical follow-up and tumor markers serial evaluation is mandatory to evaluate recurrency.

Original languageEnglish
Pages (from-to)585-591
Number of pages7
JournalIndian Journal of Obstetrics and Gynecology Research
Issue number4
Publication statusPublished - 2021
Externally publishedYes


  • Adjuvant chemotherapy
  • Granulosa cell tumor
  • Prognosis
  • Recurrency


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