TY - JOUR
T1 - Characteristics of calcified nodule attributable to culprit lesion in acute coronary syndrome
T2 - A systematic review and meta-analysis
AU - Kurniawan, Roy Bagus
AU - Saputra, Pandit Bagus Tri
AU - Haq, Alyaa Ulaa Dhiya Ul
AU - Purwati, Dinda Dwi
AU - Wungu, Citrawati Dyah Kencono
AU - Susilo, Hendri
AU - Alsagaff, Mochamad Yusuf
AU - Amin, Indah Mohd
AU - Oktaviono, Yudi Her
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/7/19
Y1 - 2024/7/19
N2 - The presence of calcified nodule (CN) is a significant characteristic of atherothrombosis in acute coronary syndrome (ACS). However, its characteristics continue to be understudied. This review aimed to further investigate these characteristics. This study found that CN was a distinctive feature of an atheromatous plaque, representing 6.3% of ACS. CN was more common in NSTE-ACS than in STEMI patients (9.4% vs. 6.6%). CN was also chiefly observed in the left anterior descendant artery (48%), followed by the right coronary (40.4%) and left circumflex (14.5%) arteries. Higher prevalence of hypertension (78.8%), diabetes mellitus (50.8%), multivessel disease (71.7%), and kidney disease (26.43%) were noted in CN compared to non-CN patients. CN-associated ACS also 6-fold increased the risk of target lesion revascularization compared to those without CN.
AB - The presence of calcified nodule (CN) is a significant characteristic of atherothrombosis in acute coronary syndrome (ACS). However, its characteristics continue to be understudied. This review aimed to further investigate these characteristics. This study found that CN was a distinctive feature of an atheromatous plaque, representing 6.3% of ACS. CN was more common in NSTE-ACS than in STEMI patients (9.4% vs. 6.6%). CN was also chiefly observed in the left anterior descendant artery (48%), followed by the right coronary (40.4%) and left circumflex (14.5%) arteries. Higher prevalence of hypertension (78.8%), diabetes mellitus (50.8%), multivessel disease (71.7%), and kidney disease (26.43%) were noted in CN compared to non-CN patients. CN-associated ACS also 6-fold increased the risk of target lesion revascularization compared to those without CN.
KW - Cardiovascular medicine
KW - Health sciences
KW - Medical specialty
KW - Medicine
UR - http://www.scopus.com/inward/record.url?scp=85198161503&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2024.110351
DO - 10.1016/j.isci.2024.110351
M3 - Article
AN - SCOPUS:85198161503
SN - 2589-0042
VL - 27
JO - iScience
JF - iScience
IS - 7
M1 - 110351
ER -
