Abstract
Aim: Inhalable microspheres made of polymers as a targeted drug delivery system have been developed to overcome the limitation of current treatments in Tuberculosis. Materials & methods: Isoniazid inhalable microspheres were created using a gelation ionotropic method with sodium alginate, carrageenan and calcium chloride in four different formulations. Result: The particle morphology has smooth surfaces and round spherical shapes with sizes below 5 μm; good flowability. The drug loading and entrapment efficiency values ranged from 1.69 to 2.75% and 62.44 to 85.30%, respectively. The microspheres drug release followed the Korsmeyer-Peppas model, indicating Fickian diffusion. Conclusion: Isoniazid inhalable microspheres achieved as targeted lung delivery for tuberculosis treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 689-704 |
| Number of pages | 16 |
| Journal | Therapeutic Delivery |
| Volume | 14 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 1 Nov 2023 |
Keywords
- alginate
- carrageenan
- characteristics
- drug release
- inhalation
- isoniazid
- microspheres
- pulmonary disease
- tuberculosis
