Characteristics and release of isoniazid from inhalable alginate/carrageenan microspheres

Yotomi Desia Eka Rani, Mahardian Rahmadi, Dewi Melani Hariyadi

Research output: Contribution to journalArticlepeer-review


Aim: Inhalable microspheres made of polymers as a targeted drug delivery system have been developed to overcome the limitation of current treatments in Tuberculosis. Materials & methods: Isoniazid inhalable microspheres were created using a gelation ionotropic method with sodium alginate, carrageenan and calcium chloride in four different formulations. Result: The particle morphology has smooth surfaces and round spherical shapes with sizes below 5 μm; good flowability. The drug loading and entrapment efficiency values ranged from 1.69 to 2.75% and 62.44 to 85.30%, respectively. The microspheres drug release followed the Korsmeyer-Peppas model, indicating Fickian diffusion. Conclusion: Isoniazid inhalable microspheres achieved as targeted lung delivery for tuberculosis treatment.

Original languageEnglish
Pages (from-to)689-704
Number of pages16
JournalTherapeutic Delivery
Issue number11
Publication statusPublished - 1 Nov 2023


  • alginate
  • carrageenan
  • characteristics
  • drug release
  • inhalation
  • isoniazid
  • microspheres
  • pulmonary disease
  • tuberculosis


Dive into the research topics of 'Characteristics and release of isoniazid from inhalable alginate/carrageenan microspheres'. Together they form a unique fingerprint.

Cite this