Abstract
The present study investigated the characteristics of diclofenac diethylammonium-containing NLC as function of ratio of glyceryl monostearate (GMS) and caprylic acid (mygliol 80) of 65:35; 75:25 and 85:15. There were three formulas and the composition of each formula were diclofenac diethylammonium 1.16%; glyceryl monostearate and caprylic acid with ratio (65:35; 75:25 and 85:15); Tween 80 5%; and phosphate buffer pH 6.0 ± 0.1 as dispersion medium. The result showed that each formula had different characteristic of particle size and efficiency entrapment. Particle size was analized by Delsa™Nano, F I (65:35) had particle size 134.467 ± 26.601 nm with PI 11.776; F II (75:25) had particle size 2252.233 ± 727.370 nm with PI 0.348; and F III (85:15) had particle size 1500.867 ± 219.673 nm with PI 0.260. The present Entrapment Efficiency (EE) carried out by centrifuge method and result of F I, F II and F III were 88.342 ± 0.52%, 73.764 ± 0.511% and 70.754 ± 0.665%, respectively. The result was analyzed by statistic with ANOVA one-way method with degree of confident 95% (α = 0.005). Research result revealed that the best characteristics of diclofenac diethylammonium in terms of particle size and % Entrapment Efficiency (EE) was F I with ratio of GMS and caprylic acid (mygliol 80) 65:35.
| Original language | English |
|---|---|
| Pages (from-to) | 1699-1704 |
| Number of pages | 6 |
| Journal | Research Journal of Pharmacy and Technology |
| Volume | 14 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2021 |
Keywords
- Caprylic Acid
- Diclofenac Diethylammonium
- Glyseryl Monostearate
- NLC
- Tween 80