TY - JOUR
T1 - Challenges and strategy in treatment with exosomes for cell-free-based tissue engineering in dentistry
AU - Ana, Ika Dewi
AU - Barlian, Anggraini
AU - Hidajah, Atik Choirul
AU - Wijaya, Christofora Hanny
AU - Notobroto, Hari Basuki
AU - Kencana Wungu, Triati Dewi
N1 - Funding Information:
This study is supported by Indonesia Collaborative Research (RKI) Funding Scheme under World Class University Acceleration Program from the Ministry of Education, Culture, Research, and Technology of the Republic of Indonesia, with a contract number 810/UN1/Ditlit/Dit-Lit/PT/2020. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
Publisher Copyright:
© 2021 Ika Dewi Ana.
PY - 2021/12
Y1 - 2021/12
N2 - In dentistry, problems of craniofacial, osteochondral, periodontal tissue, nerve, pulp or endodontics injuries, and osteoarthritis need regenerative therapy. The use of stem cells in dental tissue engineering pays a lot of increased attention, but there are challenges for its clinical applications. Therefore, cell-free-based tissue engineering using exosomes isolated from stem cells is regarded an alternative approach in regenerative dentistry. However, practical use of exosome is restricted by limited secretion capability of cells. For future regenerative treatment with exosomes, efficient strategies for large-scale clinical applications are being studied, including the use of ceramics-based scaffold to enhance exosome production and secretion which can resolve limited exosome secretory from the cells when compared with the existing methods available. Indeed, more research needs to be done on these strategies going forward.
AB - In dentistry, problems of craniofacial, osteochondral, periodontal tissue, nerve, pulp or endodontics injuries, and osteoarthritis need regenerative therapy. The use of stem cells in dental tissue engineering pays a lot of increased attention, but there are challenges for its clinical applications. Therefore, cell-free-based tissue engineering using exosomes isolated from stem cells is regarded an alternative approach in regenerative dentistry. However, practical use of exosome is restricted by limited secretion capability of cells. For future regenerative treatment with exosomes, efficient strategies for large-scale clinical applications are being studied, including the use of ceramics-based scaffold to enhance exosome production and secretion which can resolve limited exosome secretory from the cells when compared with the existing methods available. Indeed, more research needs to be done on these strategies going forward.
KW - MSC
KW - cell-free-based therapy
KW - ceramics-based scaffold
KW - exosome
KW - regenerative dentistry
KW - tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85119989416&partnerID=8YFLogxK
U2 - 10.2144/fsoa-2021-0050
DO - 10.2144/fsoa-2021-0050
M3 - Review article
AN - SCOPUS:85119989416
VL - 7
JO - Future Science OA
JF - Future Science OA
SN - 2056-5623
IS - 10
M1 - 20210050
ER -