TY - JOUR
T1 - Chalcones
T2 - Synthesis, Structure diversity and pharmacological aspects
AU - Suwito, Hery
AU - Jumina,
AU - Mustofa,
AU - Kristanti, Alfinda Novi
AU - Puspaningsih, Ni Nyoman Tri
N1 - Publisher Copyright:
© 2014, Journal of Chemical and Pharmaceutical Research. All Rights Reserved.
PY - 2014
Y1 - 2014
N2 - The diverse pharmacological activities of chalcones, such as antioxidant, antimicrobial, anticancer, and antihepatotoxic, attract many researchers to isolate and elucidate them from nature and to develop efficient synthetic method. In the development, chalcones do not only comprise derivatives of trans-1,3-diaryl-2-propen-1- ones, but also their analog. Chalcones isolated from nature show exotic structure, which is sometime unrecognizable directly. The structure diversity of chalcone whether from nature or synthetic origin and various synthetic method of chalcone are discussed. Furthermore the bi-electrophile character of chalcone makes them more attractive to be used as synthon in the synthesis of heterocyclic compounds, such as pyrazoline, pyrimidinone, and benzazepine, through cyclo-condensation reaction with a bi-nucleophilic species.
AB - The diverse pharmacological activities of chalcones, such as antioxidant, antimicrobial, anticancer, and antihepatotoxic, attract many researchers to isolate and elucidate them from nature and to develop efficient synthetic method. In the development, chalcones do not only comprise derivatives of trans-1,3-diaryl-2-propen-1- ones, but also their analog. Chalcones isolated from nature show exotic structure, which is sometime unrecognizable directly. The structure diversity of chalcone whether from nature or synthetic origin and various synthetic method of chalcone are discussed. Furthermore the bi-electrophile character of chalcone makes them more attractive to be used as synthon in the synthesis of heterocyclic compounds, such as pyrazoline, pyrimidinone, and benzazepine, through cyclo-condensation reaction with a bi-nucleophilic species.
KW - Benzazepine
KW - Pyrazoline
KW - Pyrimidinone
KW - chalcone
UR - http://www.scopus.com/inward/record.url?scp=84907090870&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84907090870
SN - 0975-7384
VL - 6
SP - 1076
EP - 1088
JO - Journal of Chemical and Pharmaceutical Research
JF - Journal of Chemical and Pharmaceutical Research
IS - 5
ER -