Cassiarins C-E, antiplasmodial alkaloids from the flowers of Cassia siamea

Shiori Oshimi; Jun Deguchi; Yusuke Hirasawa; Wiwied Ekasari; Aty Widyawaruyanti; Tutik Sri Wahyuni; Noor Cholies Zaini; Osamu Shirota; Hiroshi Morita

doi:10.1021/np9004213

Cassiarins C-E, antiplasmodial alkaloids from the flowers of Cassia siamea

Shiori Oshimi, Jun Deguchi, Yusuke Hirasawa, Wiwied Ekasari, Aty Widyawaruyanti, Tutik Sri Wahyuni, Noor Cholies Zaini, Osamu Shirota, Hiroshi Morita

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60 Citations (Scopus)

Abstract

Three new alkaloids, cassiarins C-E (1-3), and a new chromone, 10,11-dihydroanhydrobarakol (4), which showed moderate antiplasmodial activity against Plasmodium falciparum 3D7, were isolated from flowers of Cassia siamea, and the structures of 1-4 were elucidated by 2D NMR analysis and chemical transformation. Cassiarin D (2) was a dimeric compound consisting of 5-acetonyl-7-hydroxy-2-methylchromone and cassiarin C (1), and cassiarin E (3) was a dimer of cassiarins A and C (1).

Original language	English
Pages (from-to)	1899-1901
Number of pages	3
Journal	Journal of Natural Products
Volume	72
Issue number	10
DOIs	https://doi.org/10.1021/np9004213
Publication status	Published - 23 Oct 2009

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title = "Cassiarins C-E, antiplasmodial alkaloids from the flowers of Cassia siamea",

abstract = "Three new alkaloids, cassiarins C-E (1-3), and a new chromone, 10,11-dihydroanhydrobarakol (4), which showed moderate antiplasmodial activity against Plasmodium falciparum 3D7, were isolated from flowers of Cassia siamea, and the structures of 1-4 were elucidated by 2D NMR analysis and chemical transformation. Cassiarin D (2) was a dimeric compound consisting of 5-acetonyl-7-hydroxy-2-methylchromone and cassiarin C (1), and cassiarin E (3) was a dimer of cassiarins A and C (1).",

author = "Shiori Oshimi and Jun Deguchi and Yusuke Hirasawa and Wiwied Ekasari and Aty Widyawaruyanti and Wahyuni, \{Tutik Sri\} and Zaini, \{Noor Cholies\} and Osamu Shirota and Hiroshi Morita",

year = "2009",

month = oct,

day = "23",

doi = "10.1021/np9004213",

language = "English",

volume = "72",

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journal = "Journal of Natural Products",

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TY - JOUR

T1 - Cassiarins C-E, antiplasmodial alkaloids from the flowers of Cassia siamea

AU - Oshimi, Shiori

AU - Deguchi, Jun

AU - Hirasawa, Yusuke

AU - Ekasari, Wiwied

AU - Widyawaruyanti, Aty

AU - Wahyuni, Tutik Sri

AU - Zaini, Noor Cholies

AU - Shirota, Osamu

AU - Morita, Hiroshi

PY - 2009/10/23

Y1 - 2009/10/23

N2 - Three new alkaloids, cassiarins C-E (1-3), and a new chromone, 10,11-dihydroanhydrobarakol (4), which showed moderate antiplasmodial activity against Plasmodium falciparum 3D7, were isolated from flowers of Cassia siamea, and the structures of 1-4 were elucidated by 2D NMR analysis and chemical transformation. Cassiarin D (2) was a dimeric compound consisting of 5-acetonyl-7-hydroxy-2-methylchromone and cassiarin C (1), and cassiarin E (3) was a dimer of cassiarins A and C (1).

AB - Three new alkaloids, cassiarins C-E (1-3), and a new chromone, 10,11-dihydroanhydrobarakol (4), which showed moderate antiplasmodial activity against Plasmodium falciparum 3D7, were isolated from flowers of Cassia siamea, and the structures of 1-4 were elucidated by 2D NMR analysis and chemical transformation. Cassiarin D (2) was a dimeric compound consisting of 5-acetonyl-7-hydroxy-2-methylchromone and cassiarin C (1), and cassiarin E (3) was a dimer of cassiarins A and C (1).

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M3 - Article

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SN - 0163-3864

VL - 72

SP - 1899

EP - 1901

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 10

ER -

Cassiarins C-E, antiplasmodial alkaloids from the flowers of Cassia siamea

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