Cassiarins C-E, antiplasmodial alkaloids from the flowers of Cassia siamea

Shiori Oshimi, Jun Deguchi, Yusuke Hirasawa, Wiwied Ekasari, Aty Widyawaruyanti, Tutik Sri Wahyuni, Noor Cholies Zaini, Osamu Shirota, Hiroshi Morita

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55 Citations (Scopus)

Abstract

Three new alkaloids, cassiarins C-E (1-3), and a new chromone, 10,11-dihydroanhydrobarakol (4), which showed moderate antiplasmodial activity against Plasmodium falciparum 3D7, were isolated from flowers of Cassia siamea, and the structures of 1-4 were elucidated by 2D NMR analysis and chemical transformation. Cassiarin D (2) was a dimeric compound consisting of 5-acetonyl-7-hydroxy-2-methylchromone and cassiarin C (1), and cassiarin E (3) was a dimer of cassiarins A and C (1).

Original languageEnglish
Pages (from-to)1899-1901
Number of pages3
JournalJournal of Natural Products
Volume72
Issue number10
DOIs
Publication statusPublished - 23 Oct 2009

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