Eka Dian Sofiana, Mustofa Helmi Effendi, Hani Plumeriastuti, Junianto Wika Adi Pratama

Research output: Contribution to journalArticlepeer-review


Antibiotics are commonly used in veterinary medicine throughout the world for therapeutic uses and for increasing production in pig farms. Klebsiella pneumoniae is one of the most important organisms clinically that has received attention in public health. Klebsiella pneumoniae (K. pneumoniae) is a group of Enterobacteriaceae which is significant for causing disease and shows frequent resistance to antibiotics in humans as well as in pigs. This study aims to determine the antibiotic resistance profile in pig farms through the identification of K. pneumoniae, which is one of the important bacteria involved in antibiotic resistance. This study focuses on the presence of K. pneumoniae bacteria in pigs carried out by rectal swabs on two pig farms in East Java, namely the pig farms in Gresik Regency and Malang Regency. The samples obtained were cultured using Mac Conkey Agar media and tested for biochemical identification and antibiotic sensitivity testing with the Kirby-Bauer method against the antibiotics ciprofloxacin, streptomycin, trimethoprim, tetracyclin and aztreonam. The K. pneumoniae bacteria was isolated from 7 samples of swine rectal swabs from pig farms in Gresik Regency and 4 samples from pig farms in Malang Regency. Of the 11 positive samples of K. pneumoniae, almost all isolates were resistant to tetracyclin and trimethoprim antibiotics. There were 4 K. pneumoniae isolates that were resistant to 3 antibiotics (MDR). It can be concluded that K. pneumoniae has potential to become a serious problem on public health.

Original languageEnglish
Pages (from-to)1979-1985
Number of pages7
JournalBiochemical and Cellular Archives
Publication statusPublished - Aug 2021


  • Antibiotic resistance
  • Klebsiella pneumoniae
  • multidrug resistance
  • pigs
  • public health


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