Case report: Two confirmed cases of human Seoul virus infections in Indonesia

Khie Chen Lie, Mochamad Helmi Aziz, Herman Kosasih, Aaron Neal, Caleb Leonardo Halim, Wahyu Nawang Wulan, Muhammad Karyana, Usman Hadi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Background: Seoul virus (SEOV) is a member of hantavirus family, which is transmitted to humans by Rattus rattus and Rattus norvegicus. Diagnosing SEOV infection is difficult because the clinical presentations are often undifferentiated with other viral or bacterial infections and assays to test antibodies seroconversion and RNA detection are not available in resource-limited setting like Indonesia. Case presentation: We report two confirmed cases of SEOV infection from Indonesia. Here, we illustrate the clinical presentations, hematology and biochemistry profiles, and outcomes of the two cases. Phylogenetic analysis revealed that SEOV sequences have highest homology to isolates obtained from rodents in Indonesia. Conclusions: This report highlights the importance of considering SEOV infection in febrile patients with lymphopenia, thrombocytopenia, and elevation of liver enzyme despite the absence of hemorrhagic manifestations and renal syndromes. The public health importance of rodent-borne diseases such as SEOV infection urges an integrated epidemiological surveillance both in humans and rodents in Indonesia.

Original languageEnglish
Article number578
JournalBMC Infectious Diseases
Issue number1
Publication statusPublished - 16 Nov 2018


  • Detection
  • Indonesia
  • Seoul virus


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