Cardiovascular disorders and obstructive sleep apnea

Afrita Amalia Laitupa, R. P.Soeharsohadi Tjondronegoro

Research output: Contribution to journalArticlepeer-review


Obstructive sleep apnea (OSA) is associated with an increased risk of hypertension, coronary heart disease, heart failure and arrhythmias. The prevalence and severity of OSA in cardiovascular disease are increase with age. Mechanism of OSA in cardiovascular disorders associated with oxidative stress, sympathetic activation, inflammation, hypercoagulability, endothelial dysfunction, sleep fragmentation and metabolic dysregulation. Although polysomnography is a gold standard diagnostic tool of OSA but it is still expensive, does require questionnaires as a tool for OSA detection. The treatments consist of continuous positive airway pressure (CPAP), oral appliances, surgical and behavioral modification.

Original languageEnglish
Pages (from-to)2159-2164
Number of pages6
JournalInternational Journal of Pharmaceutical Research
Issue number1
Publication statusPublished - 1 Jan 2020


  • Cardiovascular disorders
  • CPAP
  • Sympathetic nerve activity


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