Cardioprotective properties of glucagon-like peptide-1 receptor agonists in type 2 diabetes mellitus patients: A systematic review

Wynne Widiarti, Alverina Cynthia Sukmajaya, David Nugraha, Firas Farisi Alkaff

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)


Background and aims: Cardiovascular disease is one of the main contributors for the mortality in type 2 diabetes mellitus (T2DM) patients. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) had shown cardiovascular benefits which may be advantageous to reduce mortality in T2DM patients. This systematic review focused on analyzing the effects of GLP-1 RAs on cardiovascular outcomes. Methods: We conducted an extensive search through JSTOR, PubMed, Scopus, EBSCohost, and CENTRAL. All related studies assessing the use of GLP-1 RAs in T2DM patients from inception up to October 2020 were screened. Any cardioprotective properties as the outcomes were obtained. Results: A total of six studies (4 randomized, 2 observational) with a total of 182.205 patients were included in this review. The GLP-1 RAs used were either liraglutide or exenatide in combination with antihypertensive or antilipidemic drugs. All studies showed that GLP-1 RA significantly caused weight loss and improved cardiac functional capacity by increasing left ventricular ejection fraction and reducing end-systolic and end-diastolic left ventricle volume. GLP-1 RA also improved myocardial blood flow without affecting myocardial glucose uptake. However, GLP-1 RA failed to show its effect in reducing blood pressure and improving lipid profiles. Conclusions: Despite the limited number of studies, consistent data showed that GLP-1 RA has several cardioprotective properties.

Original languageEnglish
Pages (from-to)837-843
Number of pages7
JournalDiabetes and Metabolic Syndrome: Clinical Research and Reviews
Issue number3
Publication statusPublished - 1 May 2021


  • Antidiabetic drugs
  • Cardioprotective agents
  • Glucagon-like Peptide-1 receptor
  • Systematic review
  • Type 2 diabetes mellitus


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