Carboxymethyl Chitosan Nano-Fibers for Controlled Releasing 5-Fluorouracil Anticancer Drug

Indah Raya, Supat Chupradit, Yasser Fakri Mustafa, Khulood H. Oudaha, Mustafa M. Kadhim, Abduladheem Turki Jalil, Abed J. Kadhim, Trias Mahmudiono, Lakshmi Thangavelu

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20 Citations (Scopus)


In the present study, the pH responsive electrospun carboxymethyl chitosan nanofibers were prepared via electrospinning method and cross-linked with glutaraldehyde vapor for various times up to 48 h. The controlled release of 5-Fluorouracil (5-FU) from single layer and trilayered nanofibers (5-FU in the middle layer) was compared to obtain a sustained delivery system of 5-FU anticancer drug. The release of 5-FU from nanofibers was investigated at 37 °C under acidic pH (pH 5.5) and physiological pH (pH 7.4). The release data were fitted by zero-order, Higuchi and Korsmeyer-Peppas pharmacokinetic equations to determine the 5-FU release mechanism from nanofibers. Tri-layered nanofibers exhibited the sustained delivery of 5-FU without initial burst release during 168 and 216 h at pH=5.5 and 7.4, respectively. The initial burst release followed by sustained release of 5-FU from single layer crosslinked carboxymethyl chitosan nanofibers occurred during 48 and 60 h. The “n” constant of Korsmeyer-Peppas equation indicated the non Fickian diffusion of 5-FU from single layer nanofibers at both pH values of 5.5, pH 7.4 and tri-layered nanofibers at pH 5.5. Whereas, the Fickian diffusion of 5-FU was occurred from tri-layered nanofibers at pH 7.4. The obtained results indicated the high capability of tri-layered nanofibers for controlled release of 5-FU compared to single layer nanofibers.

Original languageEnglish
Pages (from-to)136-143
Number of pages8
JournalJournal of Nanostructures
Issue number1
Publication statusPublished - Dec 2022


  • 5-Fluorouracil
  • Anticancer Drug
  • Carboxymethyl Chitosan
  • Nano Fibers
  • Pharmacokinetic
  • pH responsive


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