Carbazomarin: A new potential of α-glucosidase inhibitor from clausena excavata roots

Nanik S. Aminah, Tin M. Thant, Alfinda N. Kristanti, Rico Ramadhan, Hnin T. Aung, Yoshiaki Takaya

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Continuing our exploration for dual functions antidiabetic and antioxidant agents from Myanmar medicinal plant, a new carbazole-pyranocoumarin conjugate, carbazomarin-C (1) along with a known carbazole alkaloid, mukonine (2) and a pyranocoumarin, xan-thoxyletin (3), was isolated from the roots of Clausena excavata. The chemical structures of these compounds were identified using a combination of spectroscopic methods. Among isolates, there was a strong inhibition of compounds (1) and (3) on yeast α-glu-cosidase in a dose-dependent manner. It was shown when p-nitrophenyl-α-d-glucopyranoside was used as a substrate in vitro with IC50 values 0.22 and 4.81 mM, respectively. However, all isolated compounds displayed no inhibition against DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalNatural Product Communications
Volume14
Issue number12
DOIs
Publication statusPublished - 2019

Keywords

  • Carbazole alkaloid
  • Carbazomarin-C
  • Clausena excavata
  • Coumarin
  • DPPH
  • α-glycosidase

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