Abstract
Continuing our exploration for dual functions antidiabetic and antioxidant agents from Myanmar medicinal plant, a new carbazole-pyranocoumarin conjugate, carbazomarin-C (1) along with a known carbazole alkaloid, mukonine (2) and a pyranocoumarin, xan-thoxyletin (3), was isolated from the roots of Clausena excavata. The chemical structures of these compounds were identified using a combination of spectroscopic methods. Among isolates, there was a strong inhibition of compounds (1) and (3) on yeast α-glu-cosidase in a dose-dependent manner. It was shown when p-nitrophenyl-α-d-glucopyranoside was used as a substrate in vitro with IC50 values 0.22 and 4.81 mM, respectively. However, all isolated compounds displayed no inhibition against DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals.
Original language | English |
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Pages (from-to) | 1-5 |
Number of pages | 5 |
Journal | Natural Product Communications |
Volume | 14 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2019 |
Keywords
- Carbazole alkaloid
- Carbazomarin-C
- Clausena excavata
- Coumarin
- DPPH
- α-glycosidase