Camellia sinensis with its active compound egcg can decrease necroptosis via inhibition of ho-1 expression

Stroke is the most common neurological disorder in the word. During ischemic stroke there is increasing of oxidative stress. Green tea (Camellia sinensis) have antioxidant and free radical scavenger effect. In vivo study using male Rattus Novergicus with 5 group, control MCAO group, EGCG 10 mg/kgBW, EGCG 20 mg/ kgBW, EGCG 30 mg/kgBW, extract green tea 30 mg/kgBW. Treatment is for 7 days before sacrifice and perform brain tissue IHC examination for HO-1, TNFR1, and RIP3. There is significant different in HO-1 expression started at 10 mg/kgBW treatment (p = 0.013). Significant different on TNFR1 started at group EGCG 20 mg/kgBW (p = 0.004), there is significant different on RIP3 started at EGCG 20 mg/kgBW group (p = 0.002). There is correlation between HO-1 and TNFR1 (r = 0.497; p = 0.000), TNFR1 and RIP3 (r = 0.551; p = 0.000) and HO-1 and RIP3 (r =-0.433; p = 0.001). Camellia sinensis with its active compound EGCG decrease RIP3 expression through down regulation of HO-1.